| pubmed-article:1569401 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1569401 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:1569401 | lifeskim:mentions | umls-concept:C0221117 | lld:lifeskim |
| pubmed-article:1569401 | lifeskim:mentions | umls-concept:C0879590 | lld:lifeskim |
| pubmed-article:1569401 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:1569401 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1569401 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1569401 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1569401 | pubmed:dateCreated | 1992-5-26 | lld:pubmed |
| pubmed-article:1569401 | pubmed:abstractText | T cell activation requires two distinct signals. The first is delivered through the antigen-specific T cell receptor (TCR), and the second is provided by costimulatory molecule(s) present on the surface of the antigen-presenting cell (APC). Stimulation of T helper type 1 T cell clones through the TCR in the absence of the costimulatory activity results in a lack of interleukin 2 (IL-2) secretion and proliferation, and the induction of a long-lived state of nonresponsiveness, termed anergy. In this study, we have examined the transcription factors involved in IL-2 gene expression that are expressed after stimulation of normal T cell clones through the TCR with and without engagement of the necessary costimulatory molecule(s). Antigen-specific activation of the clones results in the induction of a similar pattern of transcription factors that have been previously shown to regulate IL-2 expression. In contrast, antigen presentation by chemically fixed APC, a condition that results in T cell anergy, induces neither NF-AT nor one of the two NF-kappa B binding factors. Thus, the failure to express IL-2 during the induction of T cell anergy may be attributed to the absence of these two transcription factors. When anergized T cells are restimulated with antigen and conventional APC, they induce the transcription factors associated with IL-2 expression, but they fail to synthesize measurable IL-2. Taken together, these data indicate that the control of IL-2 gene expression during anergy induction and during normal stimulation of anergized cells are distinct, and suggest the presence of additional regulatory elements in the IL-2 gene. | lld:pubmed |
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| pubmed-article:1569401 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1569401 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1569401 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1569401 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1569401 | pubmed:month | May | lld:pubmed |
| pubmed-article:1569401 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:1569401 | pubmed:author | pubmed-author:MillerJJ | lld:pubmed |
| pubmed-article:1569401 | pubmed:author | pubmed-author:HUFF | lld:pubmed |
| pubmed-article:1569401 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1569401 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1569401 | pubmed:volume | 175 | lld:pubmed |
| pubmed-article:1569401 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1569401 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1569401 | pubmed:pagination | 1327-36 | lld:pubmed |
| pubmed-article:1569401 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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