| pubmed-article:15693956 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15693956 | lifeskim:mentions | umls-concept:C0679215 | lld:lifeskim |
| pubmed-article:15693956 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:15693956 | lifeskim:mentions | umls-concept:C0078058 | lld:lifeskim |
| pubmed-article:15693956 | lifeskim:mentions | umls-concept:C0002976 | lld:lifeskim |
| pubmed-article:15693956 | lifeskim:mentions | umls-concept:C1171892 | lld:lifeskim |
| pubmed-article:15693956 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15693956 | pubmed:dateCreated | 2005-2-7 | lld:pubmed |
| pubmed-article:15693956 | pubmed:abstractText | Vascular endothelial growth factors (VEGFs) are a family of secreted polypeptides with a highly conserved receptor-binding cystine-knot structure similar to that of the platelet-derived growth factors. VEGF-A, the founding member of the family, is highly conserved between animals as evolutionarily distant as fish and mammals. In vertebrates, VEGFs act through a family of cognate receptor kinases in endothelial cells to stimulate blood-vessel formation. VEGF-A has important roles in mammalian vascular development and in diseases involving abnormal growth of blood vessels; other VEGFs are also involved in the development of lymphatic vessels and disease-related angiogenesis. Invertebrate homologs of VEGFs and VEGF receptors have been identified in fly, nematode and jellyfish, where they function in developmental cell migration and neurogenesis. The existence of VEGF-like molecules and their receptors in simple invertebrates without a vascular system indicates that this family of growth factors emerged at a very early stage in the evolution of multicellular organisms to mediate primordial developmental functions. | lld:pubmed |
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| pubmed-article:15693956 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15693956 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15693956 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15693956 | pubmed:issn | 1465-6914 | lld:pubmed |
| pubmed-article:15693956 | pubmed:author | pubmed-author:HolmesDavid... | lld:pubmed |
| pubmed-article:15693956 | pubmed:author | pubmed-author:ZacharyIanI | lld:pubmed |
| pubmed-article:15693956 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15693956 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:15693956 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15693956 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15693956 | pubmed:pagination | 209 | lld:pubmed |
| pubmed-article:15693956 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15693956 | pubmed:meshHeading | pubmed-meshheading:15693956... | lld:pubmed |
| pubmed-article:15693956 | pubmed:meshHeading | pubmed-meshheading:15693956... | lld:pubmed |
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| pubmed-article:15693956 | pubmed:meshHeading | pubmed-meshheading:15693956... | lld:pubmed |
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| pubmed-article:15693956 | pubmed:meshHeading | pubmed-meshheading:15693956... | lld:pubmed |
| pubmed-article:15693956 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15693956 | pubmed:articleTitle | The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease. | lld:pubmed |
| pubmed-article:15693956 | pubmed:affiliation | BHF Laboratories and The Rayne Institute, Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK. | lld:pubmed |
| pubmed-article:15693956 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15693956 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:15693956 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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