| pubmed-article:1568989 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1568989 | lifeskim:mentions | umls-concept:C0011980 | lld:lifeskim |
| pubmed-article:1568989 | lifeskim:mentions | umls-concept:C0034067 | lld:lifeskim |
| pubmed-article:1568989 | lifeskim:mentions | umls-concept:C0392673 | lld:lifeskim |
| pubmed-article:1568989 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1568989 | pubmed:dateCreated | 1992-5-27 | lld:pubmed |
| pubmed-article:1568989 | pubmed:abstractText | In adult male hamsters the influence of emphysema (EMP) on the in vitro contractile and fatigue properties and the histochemical, morphometric, and metabolic properties of muscle fibers in the costal diaphragm was determined 6 mo after the administration of either elastase or saline (controls, CTL). Isometric contractile properties were determined in vitro using supramaximal direct muscle stimulation. Optimal fiber length for force generation was significantly shorter in the EMP than in the CTL diaphragm. Maximum specific force (i.e., force per unit area) was 25% lower than CTL. Fatigue resistance was significantly improved in the EMP diaphragm compared with CTL. Diaphragm muscle fibers were classified as type I or II on the basis of histochemical staining for myofibrillar adenosinetriphosphatase after alkaline preincubation. The proportions of type I and II fibers were similar between the two groups. Cross-sectional areas of type II fibers were 30% larger in EMP than in CTL diaphragms. Succinate dehydrogenase activities of both type I and II fibers were higher in EMP than in CTL diaphragms. The number of capillaries surrounding both type I and II fibers increased with EMP, but in proportion to the hypertrophy of these fibers. Thus, capillary density (number of capillaries per fiber cross-sectional area) remained unchanged. We postulate that these contractile, morphometric, and metabolic adaptations reflect an increased activation of the diaphragm in response to the loads imposed by EMP. | lld:pubmed |
| pubmed-article:1568989 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1568989 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1568989 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1568989 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1568989 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1568989 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1568989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1568989 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1568989 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1568989 | pubmed:issn | 8750-7587 | lld:pubmed |
| pubmed-article:1568989 | pubmed:author | pubmed-author:SieckG CGC | lld:pubmed |
| pubmed-article:1568989 | pubmed:author | pubmed-author:LewisM IMI | lld:pubmed |
| pubmed-article:1568989 | pubmed:author | pubmed-author:ZhanW ZWZ | lld:pubmed |
| pubmed-article:1568989 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1568989 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:1568989 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1568989 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1568989 | pubmed:pagination | 934-43 | lld:pubmed |
| pubmed-article:1568989 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1568989 | pubmed:meshHeading | pubmed-meshheading:1568989-... | lld:pubmed |
| pubmed-article:1568989 | pubmed:meshHeading | pubmed-meshheading:1568989-... | lld:pubmed |
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| pubmed-article:1568989 | pubmed:meshHeading | pubmed-meshheading:1568989-... | lld:pubmed |
| pubmed-article:1568989 | pubmed:meshHeading | pubmed-meshheading:1568989-... | lld:pubmed |
| pubmed-article:1568989 | pubmed:meshHeading | pubmed-meshheading:1568989-... | lld:pubmed |
| pubmed-article:1568989 | pubmed:meshHeading | pubmed-meshheading:1568989-... | lld:pubmed |
| pubmed-article:1568989 | pubmed:meshHeading | pubmed-meshheading:1568989-... | lld:pubmed |
| pubmed-article:1568989 | pubmed:meshHeading | pubmed-meshheading:1568989-... | lld:pubmed |
| pubmed-article:1568989 | pubmed:meshHeading | pubmed-meshheading:1568989-... | lld:pubmed |
| pubmed-article:1568989 | pubmed:meshHeading | pubmed-meshheading:1568989-... | lld:pubmed |
| pubmed-article:1568989 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1568989 | pubmed:articleTitle | Adaptations of the diaphragm in emphysema. | lld:pubmed |
| pubmed-article:1568989 | pubmed:affiliation | Department of Medicine, Cedars-Sinai Medical Center, University of California, School of Medicine, Los Angeles 90048. | lld:pubmed |
| pubmed-article:1568989 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1568989 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1568989 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1568989 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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