| pubmed-article:15688424 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15688424 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:15688424 | lifeskim:mentions | umls-concept:C0029016 | lld:lifeskim |
| pubmed-article:15688424 | lifeskim:mentions | umls-concept:C0206634 | lld:lifeskim |
| pubmed-article:15688424 | lifeskim:mentions | umls-concept:C0108685 | lld:lifeskim |
| pubmed-article:15688424 | lifeskim:mentions | umls-concept:C0332466 | lld:lifeskim |
| pubmed-article:15688424 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15688424 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15688424 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15688424 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15688424 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15688424 | pubmed:dateCreated | 2005-4-25 | lld:pubmed |
| pubmed-article:15688424 | pubmed:abstractText | The myxoid/round cell liposarcoma oncogene FUS-DDIT3 is the result of a translocation derived gene fusion between the splicing factor FUS and DDIT3. In order to investigate the downstream targets of DDIT3, and the transforming effects of the FUS-DDIT3 fusion protein, we have introduced DDIT3-GFP and FUS-DDIT3-GFP constructs into a human fibrosarcoma cell line. The gene expression profiles of stable transfectants were compared to the original fibrosarcoma cell line by microarray analysis. We here report that the NFkappaB and C/EBP beta controlled gene IL6 is upregulated in DDIT3- and FUS-DDIT3-expressing fibrosarcoma cell lines and in myxoid liposarcoma cell lines. Strong expression of the tumor associated multifunctional cytokine interleukin 6 was confirmed both at mRNA and protein level. Knockdown experiments using siRNA against CEBPB transcripts showed that the effect of FUS-DDIT3 on IL6 expression is C/EBP beta dependent. Chromatin immunoprecipitation revealed direct interaction between the IL6 promoter and the C/EBP beta protein. In addition, the effect of DDIT3 and FUS-DDIT3 on the expression of other acute phase genes was examined using real-time PCR. We demonstrate for the first time that DDIT3 and FUS-DDIT3 show opposite transcriptional regulation of IL8 and suggest that FUS-DDIT3 may affect the synergistic activation of promoters regulated by C/EBP beta and NFkappaB. | lld:pubmed |
| pubmed-article:15688424 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15688424 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15688424 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15688424 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15688424 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15688424 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:15688424 | pubmed:author | pubmed-author:AmanPierreP | lld:pubmed |
| pubmed-article:15688424 | pubmed:author | pubmed-author:GöranssonMelk... | lld:pubmed |
| pubmed-article:15688424 | pubmed:author | pubmed-author:OlofssonAnita... | lld:pubmed |
| pubmed-article:15688424 | pubmed:author | pubmed-author:StåhlbergAnde... | lld:pubmed |
| pubmed-article:15688424 | pubmed:author | pubmed-author:CayonAA | lld:pubmed |
| pubmed-article:15688424 | pubmed:author | pubmed-author:AnderssonCaro... | lld:pubmed |
| pubmed-article:15688424 | pubmed:copyrightInfo | Copyright 2005 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:15688424 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15688424 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15688424 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:15688424 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15688424 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15688424 | pubmed:pagination | 556-60 | lld:pubmed |
| pubmed-article:15688424 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15688424 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15688424 | pubmed:articleTitle | Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP beta-mediated interleukin 6 expression. | lld:pubmed |
| pubmed-article:15688424 | pubmed:affiliation | Lundberg Laboratory for Cancer Research (LLCR), Department of Pathology, Goteborg University, Gothenburg, Sweden. melker.goransson@llcr.med.gu.se | lld:pubmed |
| pubmed-article:15688424 | pubmed:publicationType | Journal Article | lld:pubmed |
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