| pubmed-article:15685193 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15685193 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:15685193 | lifeskim:mentions | umls-concept:C1101610 | lld:lifeskim |
| pubmed-article:15685193 | lifeskim:mentions | umls-concept:C0237753 | lld:lifeskim |
| pubmed-article:15685193 | lifeskim:mentions | umls-concept:C1449575 | lld:lifeskim |
| pubmed-article:15685193 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:15685193 | pubmed:issue | 7027 | lld:pubmed |
| pubmed-article:15685193 | pubmed:dateCreated | 2005-2-17 | lld:pubmed |
| pubmed-article:15685193 | pubmed:abstractText | MicroRNAs (miRNAs) are a class of noncoding RNAs that post-transcriptionally regulate gene expression in plants and animals. To investigate the influence of miRNAs on transcript levels, we transfected miRNAs into human cells and used microarrays to examine changes in the messenger RNA profile. Here we show that delivering miR-124 causes the expression profile to shift towards that of brain, the organ in which miR-124 is preferentially expressed, whereas delivering miR-1 shifts the profile towards that of muscle, where miR-1 is preferentially expressed. In each case, about 100 messages were downregulated after 12 h. The 3' untranslated regions of these messages had a significant propensity to pair to the 5' region of the miRNA, as expected if many of these messages are the direct targets of the miRNAs. Our results suggest that metazoan miRNAs can reduce the levels of many of their target transcripts, not just the amount of protein deriving from these transcripts. Moreover, miR-1 and miR-124, and presumably other tissue-specific miRNAs, seem to downregulate a far greater number of targets than previously appreciated, thereby helping to define tissue-specific gene expression in humans. | lld:pubmed |
| pubmed-article:15685193 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15685193 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15685193 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15685193 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15685193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15685193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15685193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15685193 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15685193 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15685193 | pubmed:issn | 1476-4687 | lld:pubmed |
| pubmed-article:15685193 | pubmed:author | pubmed-author:LinsleyPeter... | lld:pubmed |
| pubmed-article:15685193 | pubmed:author | pubmed-author:LauNelson CNC | lld:pubmed |
| pubmed-article:15685193 | pubmed:author | pubmed-author:BartelDavid... | lld:pubmed |
| pubmed-article:15685193 | pubmed:author | pubmed-author:LimLee PLP | lld:pubmed |
| pubmed-article:15685193 | pubmed:author | pubmed-author:GrimsonAndrew... | lld:pubmed |
| pubmed-article:15685193 | pubmed:author | pubmed-author:JohnsonJason... | lld:pubmed |
| pubmed-article:15685193 | pubmed:author | pubmed-author:Garrett-Engel... | lld:pubmed |
| pubmed-article:15685193 | pubmed:author | pubmed-author:CastleJohnJ | lld:pubmed |
| pubmed-article:15685193 | pubmed:author | pubmed-author:SchelterJanel... | lld:pubmed |
| pubmed-article:15685193 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15685193 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:15685193 | pubmed:volume | 433 | lld:pubmed |
| pubmed-article:15685193 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15685193 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15685193 | pubmed:pagination | 769-73 | lld:pubmed |
| pubmed-article:15685193 | pubmed:dateRevised | 2010-9-28 | lld:pubmed |
| pubmed-article:15685193 | pubmed:meshHeading | pubmed-meshheading:15685193... | lld:pubmed |
| pubmed-article:15685193 | pubmed:meshHeading | pubmed-meshheading:15685193... | lld:pubmed |
| pubmed-article:15685193 | pubmed:meshHeading | pubmed-meshheading:15685193... | lld:pubmed |
| pubmed-article:15685193 | pubmed:meshHeading | pubmed-meshheading:15685193... | lld:pubmed |
| pubmed-article:15685193 | pubmed:meshHeading | pubmed-meshheading:15685193... | lld:pubmed |
| pubmed-article:15685193 | pubmed:meshHeading | pubmed-meshheading:15685193... | lld:pubmed |
| pubmed-article:15685193 | pubmed:meshHeading | pubmed-meshheading:15685193... | lld:pubmed |
| pubmed-article:15685193 | pubmed:meshHeading | pubmed-meshheading:15685193... | lld:pubmed |
| pubmed-article:15685193 | pubmed:meshHeading | pubmed-meshheading:15685193... | lld:pubmed |
| pubmed-article:15685193 | pubmed:meshHeading | pubmed-meshheading:15685193... | lld:pubmed |
| pubmed-article:15685193 | pubmed:meshHeading | pubmed-meshheading:15685193... | lld:pubmed |
| pubmed-article:15685193 | pubmed:meshHeading | pubmed-meshheading:15685193... | lld:pubmed |
| pubmed-article:15685193 | pubmed:meshHeading | pubmed-meshheading:15685193... | lld:pubmed |
| pubmed-article:15685193 | pubmed:meshHeading | pubmed-meshheading:15685193... | lld:pubmed |
| pubmed-article:15685193 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15685193 | pubmed:articleTitle | Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. | lld:pubmed |
| pubmed-article:15685193 | pubmed:affiliation | Rosetta Inpharmatics, Merck and Co, 401 Terry Avenue N, Seattle, Washington 98109, USA. lee_lim@merck.com | lld:pubmed |
| pubmed-article:15685193 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15685193 | lld:pubmed |
