Linked Life Data

15680457

Source:http://linkedlifedata.com/resource/pubmed/id/15680457

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pubmed-article:15680457pubmed:abstractTextMutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been shown to cause autosomal dominant Parkinson's disease. Few mutations in this gene have been identified. We investigated the frequency of a common heterozygous mutation, 2877510 g-->A, which produces a glycine to serine aminoacid substitution at codon 2019 (Gly2019 ser), in idiopathic Parkinson's disease. We assessed 482 patients with the disorder, of whom 263 had pathologically confirmed disease, by direct sequencing for mutations in exon 41 of LRRK2. The mutation was present in eight (1.6%) patients. We have shown that a common single Mendelian mutation is implicated in sporadic Parkinson's disease. We suggest that testing for this mutation will be important in the management and genetic counselling of patients with Parkinson's disease.lld:pubmed
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pubmed-article:15680457pubmed:articleTitleA common LRRK2 mutation in idiopathic Parkinson's disease.lld:pubmed
pubmed-article:15680457pubmed:affiliationDepartment of Molecular Neuroscience, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.lld:pubmed
pubmed-article:15680457pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15680457pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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