| pubmed-article:15677474 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15677474 | lifeskim:mentions | umls-concept:C1335875 | lld:lifeskim |
| pubmed-article:15677474 | lifeskim:mentions | umls-concept:C1367307 | lld:lifeskim |
| pubmed-article:15677474 | lifeskim:mentions | umls-concept:C1705050 | lld:lifeskim |
| pubmed-article:15677474 | lifeskim:mentions | umls-concept:C0299583 | lld:lifeskim |
| pubmed-article:15677474 | lifeskim:mentions | umls-concept:C0033371 | lld:lifeskim |
| pubmed-article:15677474 | lifeskim:mentions | umls-concept:C0037663 | lld:lifeskim |
| pubmed-article:15677474 | lifeskim:mentions | umls-concept:C1518440 | lld:lifeskim |
| pubmed-article:15677474 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:15677474 | lifeskim:mentions | umls-concept:C1428898 | lld:lifeskim |
| pubmed-article:15677474 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:15677474 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:15677474 | pubmed:dateCreated | 2005-4-4 | lld:pubmed |
| pubmed-article:15677474 | pubmed:abstractText | We report here the role of one of the less studied members of the family of suppressors of cytokine signaling (SOCS), namely SOCS-7, in cytokine signaling. We demonstrate that SOCS-7 inhibits prolactin (PRL), growth hormone (GH), or leptin (LEP) signaling mediated through STAT3 and STAT5 in a dose-dependent manner. SOCS-7 also attenuated STAT3 and STAT5 signaling induced by overexpression of JH1, the catalytic subdomain of JAK2. Since SOCS-7 interacted with phosphorylated STAT3 or STAT5, we assumed that SOCS-7 acts at the level of STAT proteins. Indeed, we showed that SOCS-7 inhibits PRL- and leptin-induced STAT5 and STAT3 phosphorylation and prevented the nuclear translocation of activated STAT3. Taken together, our results indicate that SOCS-7 is a physiological dysregulator of PRL, leptin, and probably also GH signaling and that its mode of action is a novel variation of SOCS protein inhibition of cytokine-inducible STAT-mediated signal transduction. | lld:pubmed |
| pubmed-article:15677474 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15677474 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15677474 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15677474 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15677474 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15677474 | pubmed:author | pubmed-author:WeryMaximeM | lld:pubmed |
| pubmed-article:15677474 | pubmed:author | pubmed-author:GertlerAriehA | lld:pubmed |
| pubmed-article:15677474 | pubmed:author | pubmed-author:HoogheRobertR | lld:pubmed |
| pubmed-article:15677474 | pubmed:author | pubmed-author:Hooghe-Peters... | lld:pubmed |
| pubmed-article:15677474 | pubmed:author | pubmed-author:MartensNeleN | lld:pubmed |
| pubmed-article:15677474 | pubmed:author | pubmed-author:UzanGalitG | lld:pubmed |
| pubmed-article:15677474 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15677474 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:15677474 | pubmed:volume | 280 | lld:pubmed |
| pubmed-article:15677474 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15677474 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15677474 | pubmed:pagination | 13817-23 | lld:pubmed |
| pubmed-article:15677474 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:15677474 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15677474 | pubmed:articleTitle | Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. | lld:pubmed |
| pubmed-article:15677474 | pubmed:affiliation | Neuroendocrine Immunology, and Pharmacology Department, Medical School, Free University, B-1090 Brussels, Belgium. | lld:pubmed |
| pubmed-article:15677474 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15677474 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:15677474 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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