| pubmed-article:15671063 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15671063 | lifeskim:mentions | umls-concept:C1518440 | lld:lifeskim |
| pubmed-article:15671063 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:15671063 | lifeskim:mentions | umls-concept:C0752313 | lld:lifeskim |
| pubmed-article:15671063 | lifeskim:mentions | umls-concept:C2611831 | lld:lifeskim |
| pubmed-article:15671063 | pubmed:issue | Pt 4 | lld:pubmed |
| pubmed-article:15671063 | pubmed:dateCreated | 2005-2-9 | lld:pubmed |
| pubmed-article:15671063 | pubmed:abstractText | The forkhead box (FOX) transcription factor FOXM1 is ubiquitously expressed in proliferating cells. FOXM1 expression peaks at the G2/M phase of the cell cycle and its functional deficiency in mice leads to defects in mitosis. To investigate the role of FOXM1 in the cell cycle, we used synchronized hTERT-BJ1 fibroblasts to examine the cell cycle-dependent regulation of FOXM1 function. We observed that FOXM1 is localized mainly in the cytoplasm in cells at late-G1 and S phases. Nuclear translocation occurs just before entry into the G2/M phase and is associated with phosphorylation of FOXM1. Consistent with the dependency of FOXM1 function on mitogenic signals, nuclear translocation of FOXM1 requires activity of the Raf/MEK/MAPK signaling pathway and is enhanced by the MAPK activator aurintricarboxylic acid. This activating effect was suppressed by the MEK1/2 inhibitor U0126. In transient reporter assays, constitutively active MEK1 enhances the transactivating effect of FOXM1c, but not FOXM1b, on the cyclin B1 promoter. RT-PCR analysis confirmed that different cell lines and tissues predominantly express the FOXM1c transcript. Mutations of two ERK1/2 target sequences within FOXM1c completely abolish the MEK1 enhancing effect, suggesting a direct link between Raf/MEK/MAPK signaling and FOXM1 function. Importantly, inhibition of Raf/MEK/MAPK signaling by U0126 led to suppression of FOXM1 target gene expression and delayed progression through G2/M, verifying the functional relevance of FOXM1 activation by MEK1. In summary, we provide the first evidence that Raf/MEK/MAPK signaling exerts its G2/M regulatory effect via FOXM1c. | lld:pubmed |
| pubmed-article:15671063 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15671063 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15671063 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15671063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15671063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15671063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15671063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15671063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15671063 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15671063 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15671063 | pubmed:issn | 0021-9533 | lld:pubmed |
| pubmed-article:15671063 | pubmed:author | pubmed-author:YaoKwok-MingK... | lld:pubmed |
| pubmed-article:15671063 | pubmed:author | pubmed-author:TsangAnthony... | lld:pubmed |
| pubmed-article:15671063 | pubmed:author | pubmed-author:MaRichard Y... | lld:pubmed |
| pubmed-article:15671063 | pubmed:author | pubmed-author:TongTommy H... | lld:pubmed |
| pubmed-article:15671063 | pubmed:author | pubmed-author:CheungAlice... | lld:pubmed |
| pubmed-article:15671063 | pubmed:author | pubmed-author:LeungWai... | lld:pubmed |
| pubmed-article:15671063 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15671063 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15671063 | pubmed:volume | 118 | lld:pubmed |
| pubmed-article:15671063 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15671063 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15671063 | pubmed:pagination | 795-806 | lld:pubmed |
| pubmed-article:15671063 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15671063 | pubmed:meshHeading | pubmed-meshheading:15671063... | lld:pubmed |
| pubmed-article:15671063 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15671063 | pubmed:articleTitle | Raf/MEK/MAPK signaling stimulates the nuclear translocation and transactivating activity of FOXM1c. | lld:pubmed |
| pubmed-article:15671063 | pubmed:affiliation | Department of Biochemistry, Faculty of Medicine, The University of Hong Kong, 3/F Laboratory Block, The Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China. | lld:pubmed |
| pubmed-article:15671063 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15671063 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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