| pubmed-article:15670721 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15670721 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:15670721 | lifeskim:mentions | umls-concept:C0014792 | lld:lifeskim |
| pubmed-article:15670721 | lifeskim:mentions | umls-concept:C0013283 | lld:lifeskim |
| pubmed-article:15670721 | lifeskim:mentions | umls-concept:C0016952 | lld:lifeskim |
| pubmed-article:15670721 | lifeskim:mentions | umls-concept:C0017431 | lld:lifeskim |
| pubmed-article:15670721 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15670721 | pubmed:dateCreated | 2005-1-26 | lld:pubmed |
| pubmed-article:15670721 | pubmed:abstractText | We measured galactitol, galactonate, and galactose-1-phosphate in the red blood cell (RBC) to elucidate the biochemical phenotype of infants with a Duarte/galactosemia (D/G) genotype by isotope dilution GC/MS. The RBC galactonate, galactitol and Gal-1-P were quantified in 14 D/G newborns on a lactose containing formula or breast milk, eight D/G newborns on a galactose-free formula, and 18 D/G children between 1 and 2 years of age that were on a regular diet. The results were compared with those of non-galactosemic subjects of comparable age. In the D/G newborns on regular formula/breast milk, the levels of RBC galactitol, galactonate, and Gal-1-P were significantly higher than those of D/G newborns on diet treatment and non-galactosemic newborns. There was no difference in the levels of RBC galactitol, galactonate, and Gal-1-P between D/G newborns on a lactose-restricted diet and the control group. There appears to be two different responses to dietary galactose intake in D/G children. The first group of D/G children placed on a regular diet after a year of lactose restriction had higher RBC galactitol, galactonate levels than those of non-galactosemic children. The mean level of RBC galactonate was higher and the mean value of RBC galactitol was as high as that of galactosemic (G/G) patients on diet treatment. The second group of D/G children on a regular diet had normal levels of RBC galactitol and galactonate. The levels of RBC Gal-1-P were normal in both groups of D/G patients. The alternative pathway products may reflect galactose intake better than RBC Gal-1-P in D/G children. | lld:pubmed |
| pubmed-article:15670721 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15670721 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15670721 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15670721 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15670721 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15670721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15670721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15670721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15670721 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15670721 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15670721 | pubmed:issn | 1096-7192 | lld:pubmed |
| pubmed-article:15670721 | pubmed:author | pubmed-author:YagerClaireC | lld:pubmed |
| pubmed-article:15670721 | pubmed:author | pubmed-author:SegalStantonS | lld:pubmed |
| pubmed-article:15670721 | pubmed:author | pubmed-author:FiciciogluCan... | lld:pubmed |
| pubmed-article:15670721 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15670721 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:15670721 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15670721 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15670721 | pubmed:pagination | 152-9 | lld:pubmed |
| pubmed-article:15670721 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15670721 | pubmed:meshHeading | pubmed-meshheading:15670721... | lld:pubmed |
| pubmed-article:15670721 | pubmed:meshHeading | pubmed-meshheading:15670721... | lld:pubmed |
| pubmed-article:15670721 | pubmed:meshHeading | pubmed-meshheading:15670721... | lld:pubmed |
| pubmed-article:15670721 | pubmed:meshHeading | pubmed-meshheading:15670721... | lld:pubmed |
| pubmed-article:15670721 | pubmed:meshHeading | pubmed-meshheading:15670721... | lld:pubmed |
| pubmed-article:15670721 | pubmed:meshHeading | pubmed-meshheading:15670721... | lld:pubmed |
| pubmed-article:15670721 | pubmed:meshHeading | pubmed-meshheading:15670721... | lld:pubmed |
| pubmed-article:15670721 | pubmed:meshHeading | pubmed-meshheading:15670721... | lld:pubmed |
| pubmed-article:15670721 | pubmed:meshHeading | pubmed-meshheading:15670721... | lld:pubmed |
| pubmed-article:15670721 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15670721 | pubmed:articleTitle | Galactitol and galactonate in red blood cells of children with the Duarte/galactosemia genotype. | lld:pubmed |
| pubmed-article:15670721 | pubmed:affiliation | The Section of Biochemical Genetics and the Metabolic Research Laboratory, The Children's Hospital of Philadelphia, The Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. | lld:pubmed |
| pubmed-article:15670721 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15670721 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15670721 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15670721 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15670721 | lld:pubmed |
