| pubmed-article:1566917 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1566917 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
| pubmed-article:1566917 | lifeskim:mentions | umls-concept:C0003765 | lld:lifeskim |
| pubmed-article:1566917 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:1566917 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:1566917 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:1566917 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:1566917 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:1566917 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:1566917 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1566917 | pubmed:issue | 4 Pt 2 | lld:pubmed |
| pubmed-article:1566917 | pubmed:dateCreated | 1992-5-21 | lld:pubmed |
| pubmed-article:1566917 | pubmed:abstractText | With in vivo television microscopy, changes in arteriolar diameter to topical administration of various vasoactive agents were examined in the absence or in the presence of NG-monomethyl-L-arginine (L-NMMA, topical 100 microM) or NG-nitro-L-arginine (L-NNA, 2.5 microM, 20 microliters/min ia), specific inhibitors of endothelium-derived relaxing factor (EDRF) biosynthesis. In cremaster muscle arterioles (15-22 microns) of rats (n = 6-11), dilations to acetylcholine (1-100 ng) were significantly inhibited (60-70%) by either of the arginine analogues. This inhibition was reversed by subsequent administration of 1 mM L-arginine. Dose-dependent constriction to norepinephrine was enhanced by L-NMMA. Indomethacin treatment reduced arteriolar dilation to bradykinin (BK, 1-100 ng), which was significantly inhibited by additional administration of L-NNA. Application of L-NNA first, followed by additional indomethacin, elicited similar results. Dilations to sodium nitroprusside and adenosine were not reduced in the presence of the inhibitors. L-NMMA or L-NNA caused no change in systemic blood pressure but elicited a significant reduction in arteriolar diameter; this effect was not reversed by 1 mM L-arginine. These data demonstrate the presence of an L-arginine pathway to produce EDRF (nitric oxide) in skeletal muscle microcirculation that mediates and/or modulates arteriolar responses to vasoactive agents and could contribute to the regulation of basal vascular tone. | lld:pubmed |
| pubmed-article:1566917 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1566917 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1566917 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1566917 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1566917 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1566917 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1566917 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:1566917 | pubmed:author | pubmed-author:KollerAA | lld:pubmed |
| pubmed-article:1566917 | pubmed:author | pubmed-author:KaleyGG | lld:pubmed |
| pubmed-article:1566917 | pubmed:author | pubmed-author:MessinaE JEJ | lld:pubmed |
| pubmed-article:1566917 | pubmed:author | pubmed-author:WolinM SMS | lld:pubmed |
| pubmed-article:1566917 | pubmed:author | pubmed-author:RodenburgJ... | lld:pubmed |
| pubmed-article:1566917 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1566917 | pubmed:volume | 262 | lld:pubmed |
| pubmed-article:1566917 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1566917 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1566917 | pubmed:pagination | H987-92 | lld:pubmed |
| pubmed-article:1566917 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1566917 | pubmed:meshHeading | pubmed-meshheading:1566917-... | lld:pubmed |
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| pubmed-article:1566917 | pubmed:meshHeading | pubmed-meshheading:1566917-... | lld:pubmed |
| pubmed-article:1566917 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1566917 | pubmed:articleTitle | Regulation of arteriolar tone and responses via L-arginine pathway in skeletal muscle. | lld:pubmed |
| pubmed-article:1566917 | pubmed:affiliation | Department of Physiology, New York Medical College, Valhalla 10595. | lld:pubmed |
| pubmed-article:1566917 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1566917 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1566917 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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