Linked Life Data

15668342

Source:http://linkedlifedata.com/resource/pubmed/id/15668342

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pubmed-article:15668342pubmed:abstractTextHeart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased level of myocardial betaAR kinase 1 (betaARK1). Our previous studies have shown that inhibition of betaARK1 with the use of the Gbetagamma sequestering peptide of betaARK1 (betaARKct) can prevent cardiac dysfunction in models of heart failure. Because inhibition of betaARK activity is pivotal for amelioration of cardiac dysfunction, we investigated whether the level of betaARK1 inhibition correlates with the degree of heart failure.lld:pubmed
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pubmed-article:15668342pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:15668342pubmed:articleTitleLevel of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure.lld:pubmed
pubmed-article:15668342pubmed:affiliationDepartments of Medicine, Duke University Medical Center, Durham, NC 27710, USA.lld:pubmed
pubmed-article:15668342pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15668342pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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