| pubmed-article:15665853 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15665853 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15665853 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15665853 | lifeskim:mentions | umls-concept:C1822613 | lld:lifeskim |
| pubmed-article:15665853 | lifeskim:mentions | umls-concept:C1658773 | lld:lifeskim |
| pubmed-article:15665853 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:15665853 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:15665853 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:15665853 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:15665853 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:15665853 | lifeskim:mentions | umls-concept:C1335532 | lld:lifeskim |
| pubmed-article:15665853 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15665853 | pubmed:dateCreated | 2005-2-3 | lld:pubmed |
| pubmed-article:15665853 | pubmed:abstractText | The mechanisms that ensure centrosome duplication are poorly understood. In Caenorhabditis elegans, ZYG-1, SAS-4, SAS-5 and SPD-2 are required for centriole formation. However, it is unclear whether these proteins have functional homologues in other organisms. Here, we identify SAS-6 as a component that is required for daughter centriole formation in C. elegans. SAS-6 is a coiled-coil protein that is recruited to centrioles at the onset of the centrosome duplication cycle. Our analysis indicates that SAS-6 and SAS-5 associate and that this interaction, as well as ZYG-1 function, is required for SAS-6 centriolar recruitment. SAS-6 is the founding member of an evolutionarily conserved protein family that contains the novel PISA motif. We investigated the function of the human homologue of SAS-6. GFP-HsSAS-6 localizes to centrosomes and its overexpression results in excess foci-bearing centriolar markers. Furthermore, siRNA-mediated inactivation of HsSAS-6 in U2OS cells abrogates centrosome overduplication following aphidicolin treatment and interferes with the normal centrosome duplication cycle. Therefore, HsSAS-6 is also required for centrosome duplication, indicating that the function of SAS-6-related proteins has been widely conserved during evolution. | lld:pubmed |
| pubmed-article:15665853 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15665853 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15665853 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15665853 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15665853 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15665853 | pubmed:issn | 1465-7392 | lld:pubmed |
| pubmed-article:15665853 | pubmed:author | pubmed-author:GönczyPierreP | lld:pubmed |
| pubmed-article:15665853 | pubmed:author | pubmed-author:CeruttiLorenz... | lld:pubmed |
| pubmed-article:15665853 | pubmed:author | pubmed-author:LeidelSebasti... | lld:pubmed |
| pubmed-article:15665853 | pubmed:author | pubmed-author:BaumerKarineK | lld:pubmed |
| pubmed-article:15665853 | pubmed:author | pubmed-author:DelattreMarie... | lld:pubmed |
| pubmed-article:15665853 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15665853 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:15665853 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15665853 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15665853 | pubmed:pagination | 115-25 | lld:pubmed |
| pubmed-article:15665853 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:15665853 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15665853 | pubmed:articleTitle | SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells. | lld:pubmed |
| pubmed-article:15665853 | pubmed:affiliation | Swiss Institute for Experimental Cancer Research (ISREC), CH-1066 Epalinges/Lausanne, Switzerland. | lld:pubmed |
| pubmed-article:15665853 | pubmed:publicationType | Journal Article | lld:pubmed |
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