| pubmed-article:15664848 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15664848 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:15664848 | lifeskim:mentions | umls-concept:C0379900 | lld:lifeskim |
| pubmed-article:15664848 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:15664848 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:15664848 | lifeskim:mentions | umls-concept:C0599702 | lld:lifeskim |
| pubmed-article:15664848 | lifeskim:mentions | umls-concept:C0243076 | lld:lifeskim |
| pubmed-article:15664848 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15664848 | pubmed:dateCreated | 2005-1-24 | lld:pubmed |
| pubmed-article:15664848 | pubmed:abstractText | Starting from a high throughput screening hit, a series of 3,4-dihydro-2H-benzoxazinones has been identified with both high affinity for the 5-HT(1A) receptor and potent 5-HT reuptake inhibitory activity. The 5-(2-methyl)quinolinyloxy derivative combined high 5-HT(1A/1B/1D) receptor affinities with low intrinsic activity and potent inhibition of the 5-HT reuptake site (pK(i)8.2). This compound also had good oral bioavailability and brain penetration in the rat. | lld:pubmed |
| pubmed-article:15664848 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15664848 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15664848 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15664848 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15664848 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15664848 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15664848 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15664848 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:15664848 | pubmed:author | pubmed-author:MiddlemissDer... | lld:pubmed |
| pubmed-article:15664848 | pubmed:author | pubmed-author:PriceGary WGW | lld:pubmed |
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| pubmed-article:15664848 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:15664848 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15664848 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15664848 | pubmed:pagination | 737-41 | lld:pubmed |
| pubmed-article:15664848 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:15664848 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15664848 | pubmed:articleTitle | 3,4-Dihydro-2H-benzoxazinones are 5-HT(1A) receptor antagonists with potent 5-HT reuptake inhibitory activity. | lld:pubmed |
| pubmed-article:15664848 | pubmed:affiliation | Psychiatry Center of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. | lld:pubmed |
| pubmed-article:15664848 | pubmed:publicationType | Journal Article | lld:pubmed |
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