| pubmed-article:15664130 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15664130 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:15664130 | lifeskim:mentions | umls-concept:C0021246 | lld:lifeskim |
| pubmed-article:15664130 | lifeskim:mentions | umls-concept:C0026032 | lld:lifeskim |
| pubmed-article:15664130 | lifeskim:mentions | umls-concept:C0023779 | lld:lifeskim |
| pubmed-article:15664130 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:15664130 | pubmed:dateCreated | 2005-1-24 | lld:pubmed |
| pubmed-article:15664130 | pubmed:abstractText | Conventional lipid microspheres (LM) were prepared using soybean oil and lipid at a 5.5:1 weight ratio with lipid phase consisting of PC (phosphatidyl choline):CH (cholesterol) (1:0.5) by molar ratio. The average diameter of the particles was 150 nm. Long-circulating microspheres (S-LM) were also prepared similarly but the lipid phase consisted of PC:CH:DSPE-PEG (phosphatidyl choline:cholesterol:distearoyl phosphatidyl ethanolamine-polyethylene glycol) 1:0.5:0.16 by molar ratio. A comparative biodistribution study was conducted between free indomethacin and lipo-indomethacin (LM and S-LM) in the arthritic rats by administering the formulations at a dose equivalent to 12 mg of indomethacin/kg. It was observed that the free drug as well as the encapsulated drug followed biphasic clearance from the blood. Pharmacokinetic parameters, such as AUC(0-t), terminal half-life, MRT increased significantly when the drug was used in encapsulated form (p < 0.05). Clearance of the drug was reduced 1.4 times with the conventional lipid microspheres and was reduced three-fold when encapsulated in polyethylene glycol-coated lipid microspheres. The overall drug targeting efficiency (T(e)) with the PEG-coated lipid microspheres was 7.5-fold higher than the conventional lipid microspheres. The high accumulation of the drug in arthritic paw with S-LM system may be accounted for by the reduced uptake by RES cells, and thereby, availability for extravascularization in the inflammatory tissues. | lld:pubmed |
| pubmed-article:15664130 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15664130 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15664130 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15664130 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15664130 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15664130 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15664130 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15664130 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15664130 | pubmed:issn | 0378-5173 | lld:pubmed |
| pubmed-article:15664130 | pubmed:author | pubmed-author:DiwanP VPV | lld:pubmed |
| pubmed-article:15664130 | pubmed:author | pubmed-author:VyasS PSP | lld:pubmed |
| pubmed-article:15664130 | pubmed:author | pubmed-author:PalakurthiSS | lld:pubmed |
| pubmed-article:15664130 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15664130 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:15664130 | pubmed:volume | 290 | lld:pubmed |
| pubmed-article:15664130 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15664130 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15664130 | pubmed:pagination | 55-62 | lld:pubmed |
| pubmed-article:15664130 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15664130 | pubmed:meshHeading | pubmed-meshheading:15664130... | lld:pubmed |
| pubmed-article:15664130 | pubmed:meshHeading | pubmed-meshheading:15664130... | lld:pubmed |
| pubmed-article:15664130 | pubmed:meshHeading | pubmed-meshheading:15664130... | lld:pubmed |
| pubmed-article:15664130 | pubmed:meshHeading | pubmed-meshheading:15664130... | lld:pubmed |
| pubmed-article:15664130 | pubmed:meshHeading | pubmed-meshheading:15664130... | lld:pubmed |
| pubmed-article:15664130 | pubmed:meshHeading | pubmed-meshheading:15664130... | lld:pubmed |
| pubmed-article:15664130 | pubmed:meshHeading | pubmed-meshheading:15664130... | lld:pubmed |
| pubmed-article:15664130 | pubmed:meshHeading | pubmed-meshheading:15664130... | lld:pubmed |
| pubmed-article:15664130 | pubmed:meshHeading | pubmed-meshheading:15664130... | lld:pubmed |
| pubmed-article:15664130 | pubmed:meshHeading | pubmed-meshheading:15664130... | lld:pubmed |
| pubmed-article:15664130 | pubmed:meshHeading | pubmed-meshheading:15664130... | lld:pubmed |
| pubmed-article:15664130 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15664130 | pubmed:articleTitle | Biodisposition of PEG-coated lipid microspheres of indomethacin in arthritic rats. | lld:pubmed |
| pubmed-article:15664130 | pubmed:affiliation | College of Pharmacy, South Dakota State University, Brookings, SD 57007, USA. Srinath_palakurthi@sdstate.edu | lld:pubmed |
| pubmed-article:15664130 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15664130 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15664130 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15664130 | lld:pubmed |
