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pubmed-article:15659957pubmed:abstractTextImproving overall survival and reducing morbidity are major goals of childhood cancer research. This review explores an old idea that increased survival in childhood cancer can be achieved by inhibiting specific cancer targets. Specific therapeutic targeting would theoretically cause reduced morbidity as well as increased survival. Tumor-specific translocation-generated fusion proteins appear to be ideal tumor-specific therapeutic targets. This review will describe advances in aspects of target identification, potential for small molecule screening, and the evolution of clinical resistance to this new generation of pharmaceuticals.lld:pubmed
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pubmed-article:15659957pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:15659957pubmed:articleTitlePediatric malignancies provide unique cancer therapy targets.lld:pubmed
pubmed-article:15659957pubmed:affiliationDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.lld:pubmed
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