| pubmed-article:15659599 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15659599 | lifeskim:mentions | umls-concept:C0021083 | lld:lifeskim |
| pubmed-article:15659599 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:15659599 | lifeskim:mentions | umls-concept:C0228174 | lld:lifeskim |
| pubmed-article:15659599 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:15659599 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:15659599 | lifeskim:mentions | umls-concept:C0002716 | lld:lifeskim |
| pubmed-article:15659599 | lifeskim:mentions | umls-concept:C0085151 | lld:lifeskim |
| pubmed-article:15659599 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:15659599 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:15659599 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:15659599 | lifeskim:mentions | umls-concept:C1100714 | lld:lifeskim |
| pubmed-article:15659599 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15659599 | pubmed:dateCreated | 2005-1-20 | lld:pubmed |
| pubmed-article:15659599 | pubmed:abstractText | Passive immunization with an antibody directed against the N terminus of amyloid beta (Abeta) has recently been reported to exacerbate cerebral amyloid angiopathy (CAA)-related microhemorrhage in a transgenic animal model. Although the mechanism responsible for the deleterious interaction is unclear, a direct binding event may be required. We characterized the binding properties of several monoclonal anti-Abeta antibodies to deposited Abeta in brain parenchyma and CAA. Biochemical analyses demonstrated that the 3D6 and 10D5, two N-terminally directed antibodies, bound with high affinity to deposited forms of Abeta, whereas 266, a central domain antibody, lacked affinity for deposited Abeta. To determine whether 266 or 3D6 would exacerbate CAA-associated microhemorrhage, we treated aged PDAPP mice with either antibody for 6 weeks. We observed an increase in both the incidence and severity of CAA-associated microhemorrhage when PDAPP transgenic mice were treated with the N-terminally directed 3D6 antibody, whereas mice treated with 266 were unaffected. These results may have important implications for future immune-based therapeutic strategies for Alzheimer's disease. | lld:pubmed |
| pubmed-article:15659599 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15659599 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15659599 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15659599 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15659599 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15659599 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15659599 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15659599 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:15659599 | pubmed:author | pubmed-author:PaulSteven... | lld:pubmed |
| pubmed-article:15659599 | pubmed:author | pubmed-author:HoltzmanDavid... | lld:pubmed |
| pubmed-article:15659599 | pubmed:author | pubmed-author:HoffmanWherly... | lld:pubmed |
| pubmed-article:15659599 | pubmed:author | pubmed-author:NessDaniel... | lld:pubmed |
| pubmed-article:15659599 | pubmed:author | pubmed-author:DeMattosRonal... | lld:pubmed |
| pubmed-article:15659599 | pubmed:author | pubmed-author:BalesKelly... | lld:pubmed |
| pubmed-article:15659599 | pubmed:author | pubmed-author:RackeMargaret... | lld:pubmed |
| pubmed-article:15659599 | pubmed:author | pubmed-author:GitterBruce... | lld:pubmed |
| pubmed-article:15659599 | pubmed:author | pubmed-author:BooneLaura... | lld:pubmed |
| pubmed-article:15659599 | pubmed:author | pubmed-author:MayPatrick... | lld:pubmed |
| pubmed-article:15659599 | pubmed:author | pubmed-author:JordanWilliam... | lld:pubmed |
| pubmed-article:15659599 | pubmed:author | pubmed-author:HepburnDeena... | lld:pubmed |
| pubmed-article:15659599 | pubmed:author | pubmed-author:ParsadainianM... | lld:pubmed |
| pubmed-article:15659599 | pubmed:author | pubmed-author:BryanMatthew... | lld:pubmed |
| pubmed-article:15659599 | pubmed:author | pubmed-author:PirooziKathy... | lld:pubmed |
| pubmed-article:15659599 | pubmed:author | pubmed-author:BrownDonna... | lld:pubmed |
| pubmed-article:15659599 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15659599 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:15659599 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:15659599 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15659599 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15659599 | pubmed:pagination | 629-36 | lld:pubmed |
| pubmed-article:15659599 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:15659599 | pubmed:meshHeading | pubmed-meshheading:15659599... | lld:pubmed |
| pubmed-article:15659599 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15659599 | pubmed:articleTitle | Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta. | lld:pubmed |
| pubmed-article:15659599 | pubmed:affiliation | Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA. | lld:pubmed |
| pubmed-article:15659599 | pubmed:publicationType | Journal Article | lld:pubmed |
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