| pubmed-article:15647843 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15647843 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15647843 | lifeskim:mentions | umls-concept:C1367307 | lld:lifeskim |
| pubmed-article:15647843 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:15647843 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15647843 | lifeskim:mentions | umls-concept:C0596978 | lld:lifeskim |
| pubmed-article:15647843 | lifeskim:mentions | umls-concept:C0443221 | lld:lifeskim |
| pubmed-article:15647843 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:15647843 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:15647843 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15647843 | pubmed:dateCreated | 2005-1-13 | lld:pubmed |
| pubmed-article:15647843 | pubmed:abstractText | M1 mouse myeloid leukemia cells exhibit growth arrest and differentiation to monocytes/macrophages in response to leukemia inhibitory factor (LIF) stimulation. Although recent studies have demonstrated that STAT3 plays a central role in this process, it is unknown whether STAT3 activation alone is sufficient. To address this issue, we have established M1/STAT3ER cells, where STAT3 is selectively activated by 4-hydroxytamoxifen (4HT). 4HT stimulation did not have any effect on growth and morphology of M1/ STAT3ER cells, and did not induce the down-regulation of mRNA of c-myc and c-myb, which is necessary for M1 cell differentiation. On the other hand, mRNA of jun-B, IRF1 and p19 was increased by 4HT. DNA precipitation assay indicated that both stimulation of LIF and 4HT similarly activated STAT3ER. Introduction of a constitutive active MAP kinase kinase (MEK1) into M1/STAT3ER cells did not induce differentiation either. Together, our present data suggest that signaling other than the activation of STAT3 and MEK1 may be necessary for M1 cell-growth arrest and differentiation, while a set of early genes of LIF are induced by only STAT3 activation. | lld:pubmed |
| pubmed-article:15647843 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15647843 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15647843 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15647843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15647843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15647843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15647843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15647843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15647843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15647843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15647843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15647843 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15647843 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15647843 | pubmed:issn | 1107-3756 | lld:pubmed |
| pubmed-article:15647843 | pubmed:author | pubmed-author:HamaguchiMich... | lld:pubmed |
| pubmed-article:15647843 | pubmed:author | pubmed-author:MiyakeYozoY | lld:pubmed |
| pubmed-article:15647843 | pubmed:author | pubmed-author:YokotaTakashi... | lld:pubmed |
| pubmed-article:15647843 | pubmed:author | pubmed-author:IwamotoTakash... | lld:pubmed |
| pubmed-article:15647843 | pubmed:author | pubmed-author:YoshidaTsuneh... | lld:pubmed |
| pubmed-article:15647843 | pubmed:author | pubmed-author:AdachiKoichiK | lld:pubmed |
| pubmed-article:15647843 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15647843 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:15647843 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15647843 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15647843 | pubmed:pagination | 269-75 | lld:pubmed |
| pubmed-article:15647843 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15647843 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15647843 | pubmed:articleTitle | Functional analysis of the effect of forced activation of STAT3 on M1 mouse leukemia cells. | lld:pubmed |
| pubmed-article:15647843 | pubmed:affiliation | Department of Ophthalmology, Nagoya University School of Medicine, Showa-ku, Nagoya 466-8550, Japan. | lld:pubmed |
| pubmed-article:15647843 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15647843 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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