pubmed-article:15647285 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:15647285 | lifeskim:mentions | umls-concept:C0032285 | lld:lifeskim |
pubmed-article:15647285 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
pubmed-article:15647285 | lifeskim:mentions | umls-concept:C0679729 | lld:lifeskim |
pubmed-article:15647285 | lifeskim:mentions | umls-concept:C0214743 | lld:lifeskim |
pubmed-article:15647285 | lifeskim:mentions | umls-concept:C0538075 | lld:lifeskim |
pubmed-article:15647285 | lifeskim:mentions | umls-concept:C0700624 | lld:lifeskim |
pubmed-article:15647285 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
pubmed-article:15647285 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
pubmed-article:15647285 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
pubmed-article:15647285 | pubmed:issue | 14 | lld:pubmed |
pubmed-article:15647285 | pubmed:dateCreated | 2005-4-4 | lld:pubmed |
pubmed-article:15647285 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15647285 | pubmed:abstractText | Pulmonary eosinophilia, a hallmark pathologic feature of allergic lung disease, is regulated by interleukin-13 (IL-13) as well as the eotaxin chemokines, but the specific role of these cytokines and their cooperative interaction are only partially understood. First, we elucidated the essential role of IL-13 in the induction of the eotaxins by comparing IL-13 gene-targeted mice with wild type control mice by using an ovalbumin-induced model of allergic airway inflammation. Notably, ovalbumin-induced expressions of eotaxin-1 and eotaxin-2 mRNA in the lungs were almost completely dependent upon IL-13. Second, in order to address the specific role of eotaxin-2 in IL-13-induced pulmonary eosinophilia, we generated eotaxin-2 gene-deficient mice by homologous recombination. Notably, in contrast to observations made in eotaxin-1-deficient mice, eotaxin-2-deficient mice had normal base-line eosinophil levels in the hematopoietic tissues and gastrointestinal tract. However, following intratracheal IL-13 administration, eotaxin-2-deficient mice showed a profound reduction in airway eosinophilia compared with wild type mice. Most interestingly, the level of peribronchial lung tissue eosinophils in IL-13-treated eotaxin-2-deficient mice was indistinguishable from wild type mice. Furthermore, IL-13 lung transgenic mice genetically engineered to be deficient in eotaxin-2 had a marked reduction of luminal eosinophils. Mechanistic analysis identified IL13-induced eotaxin-2 expression by macrophages in a distinct lung compartment (luminal inflammatory cells) compared with eotaxin-1, which was expressed solely in the tissue. Taken together, these results demonstrate a cooperative mechanism between IL-13 and eotaxin-2. In particular, IL-13 mediates allergen-induced eotaxin-2 expression, and eotaxin-2 mediates IL-13-induced airway eosinophilia. | lld:pubmed |
pubmed-article:15647285 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15647285 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15647285 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15647285 | pubmed:language | eng | lld:pubmed |
pubmed-article:15647285 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15647285 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:15647285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15647285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15647285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15647285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15647285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15647285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15647285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15647285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15647285 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:15647285 | pubmed:month | Apr | lld:pubmed |
pubmed-article:15647285 | pubmed:issn | 0021-9258 | lld:pubmed |
pubmed-article:15647285 | pubmed:author | pubmed-author:RothenbergMar... | lld:pubmed |
pubmed-article:15647285 | pubmed:author | pubmed-author:MolkentinJeff... | lld:pubmed |
pubmed-article:15647285 | pubmed:author | pubmed-author:ZimmermannNiv... | lld:pubmed |
pubmed-article:15647285 | pubmed:author | pubmed-author:NikolaidisNik... | lld:pubmed |
pubmed-article:15647285 | pubmed:author | pubmed-author:PopeSamuel... | lld:pubmed |
pubmed-article:15647285 | pubmed:author | pubmed-author:FulkersonPatr... | lld:pubmed |
pubmed-article:15647285 | pubmed:author | pubmed-author:BlanchardCari... | lld:pubmed |
pubmed-article:15647285 | pubmed:author | pubmed-author:AkeiHiroko... | lld:pubmed |
pubmed-article:15647285 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:15647285 | pubmed:day | 8 | lld:pubmed |
pubmed-article:15647285 | pubmed:volume | 280 | lld:pubmed |
pubmed-article:15647285 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:15647285 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:15647285 | pubmed:pagination | 13952-61 | lld:pubmed |
pubmed-article:15647285 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:meshHeading | pubmed-meshheading:15647285... | lld:pubmed |
pubmed-article:15647285 | pubmed:year | 2005 | lld:pubmed |
pubmed-article:15647285 | pubmed:articleTitle | Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation. | lld:pubmed |
pubmed-article:15647285 | pubmed:affiliation | Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA. | lld:pubmed |
pubmed-article:15647285 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:15647285 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:15647285 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
pubmed-article:15647285 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
entrez-gene:16163 | entrezgene:pubmed | pubmed-article:15647285 | lld:entrezgene |
entrez-gene:56221 | entrezgene:pubmed | pubmed-article:15647285 | lld:entrezgene |
entrez-gene:541307 | entrezgene:pubmed | pubmed-article:15647285 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15647285 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15647285 | lld:entrezgene |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15647285 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15647285 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15647285 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15647285 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15647285 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15647285 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15647285 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15647285 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15647285 | lld:pubmed |