| pubmed-article:15644420 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15644420 | lifeskim:mentions | umls-concept:C1517162 | lld:lifeskim |
| pubmed-article:15644420 | lifeskim:mentions | umls-concept:C0014819 | lld:lifeskim |
| pubmed-article:15644420 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:15644420 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:15644420 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:15644420 | pubmed:dateCreated | 2005-4-21 | lld:pubmed |
| pubmed-article:15644420 | pubmed:abstractText | In vitro studies suggest that Ras activation is necessary for erythroid cell development. However, genetic inactivation of the Ras isoforms H-Ras, N-Ras, and K-Ras in mice reportedly did not affect adult or fetal erythropoiesis, though K-Ras(-/-) embryos were anemic. Given these discrepancies, we performed a more detailed analysis of fetal erythropoiesis in K-Ras(-/-) embryos. Day-13.5 K-Ras(-/-) embryos were pale with a marked reduction of mature erythrocytes in their fetal livers. The frequency and number of both early (erythroid burst-forming unit [BFU-E]) and late erythroid progenitors (erythroid colony-forming unit [CFU-E]) were reduced in K-Ras(-/-) fetal livers compared with wild-type controls and displayed a delay in terminal erythroid cell maturation. Further, K-Ras(-/-) hematopoietic progenitors had reduced proliferation in response to erythropoietin and Kit ligand compared with control cells. Thus, these studies identify K-Ras as a unique Ras isoform that is essential for regulating fetal erythropoiesis in vivo. | lld:pubmed |
| pubmed-article:15644420 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15644420 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15644420 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15644420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15644420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15644420 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15644420 | pubmed:month | May | lld:pubmed |
| pubmed-article:15644420 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:15644420 | pubmed:author | pubmed-author:KapurReubenR | lld:pubmed |
| pubmed-article:15644420 | pubmed:author | pubmed-author:OraziAttilioA | lld:pubmed |
| pubmed-article:15644420 | pubmed:author | pubmed-author:IngramDavid... | lld:pubmed |
| pubmed-article:15644420 | pubmed:author | pubmed-author:WenningMary... | lld:pubmed |
| pubmed-article:15644420 | pubmed:author | pubmed-author:WhiteHilaryH | lld:pubmed |
| pubmed-article:15644420 | pubmed:author | pubmed-author:KhalafWaleed... | lld:pubmed |
| pubmed-article:15644420 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15644420 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15644420 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:15644420 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15644420 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15644420 | pubmed:pagination | 3538-41 | lld:pubmed |
| pubmed-article:15644420 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15644420 | pubmed:meshHeading | pubmed-meshheading:15644420... | lld:pubmed |
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| pubmed-article:15644420 | pubmed:meshHeading | pubmed-meshheading:15644420... | lld:pubmed |
| pubmed-article:15644420 | pubmed:meshHeading | pubmed-meshheading:15644420... | lld:pubmed |
| pubmed-article:15644420 | pubmed:meshHeading | pubmed-meshheading:15644420... | lld:pubmed |
| pubmed-article:15644420 | pubmed:meshHeading | pubmed-meshheading:15644420... | lld:pubmed |
| pubmed-article:15644420 | pubmed:meshHeading | pubmed-meshheading:15644420... | lld:pubmed |
| pubmed-article:15644420 | pubmed:meshHeading | pubmed-meshheading:15644420... | lld:pubmed |
| pubmed-article:15644420 | pubmed:meshHeading | pubmed-meshheading:15644420... | lld:pubmed |
| pubmed-article:15644420 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15644420 | pubmed:articleTitle | K-Ras is essential for normal fetal liver erythropoiesis. | lld:pubmed |
| pubmed-article:15644420 | pubmed:affiliation | Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, 1044 W Walnut St R4/470, Indianapolis, IN 46202, USA. | lld:pubmed |
| pubmed-article:15644420 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15644420 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16653 | entrezgene:pubmed | pubmed-article:15644420 | lld:entrezgene |
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