| pubmed-article:1563726 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1563726 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:1563726 | lifeskim:mentions | umls-concept:C0751318 | lld:lifeskim |
| pubmed-article:1563726 | lifeskim:mentions | umls-concept:C0004927 | lld:lifeskim |
| pubmed-article:1563726 | lifeskim:mentions | umls-concept:C0524466 | lld:lifeskim |
| pubmed-article:1563726 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:1563726 | lifeskim:mentions | umls-concept:C0720298 | lld:lifeskim |
| pubmed-article:1563726 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1563726 | pubmed:dateCreated | 1992-5-19 | lld:pubmed |
| pubmed-article:1563726 | pubmed:abstractText | Two experiments in house mice (Mus domesticus) examined the neural sites at which steroid hormones activate the following male-typical behaviors: 70 kHz ultrasonic mating vocalizations in response to stimulus females or their urine, urinary marking in response to stimulus males or stimulus females, mounting of estrous females, and intermale aggression. In the first experiment, four groups of castrated males received bilateral intracranial implants of testosterone (T) into either the septum (SEPTUM), medial preoptic area (MPO), anterior hypothalamus (AHA), or ventromedial hypothalamus (VMH). Two control groups received subcutaneous silastic capsules of T (TSIL) or empty silastic capsules (BSIL). The TSIL males performed all behaviors at male-typical levels while the BSIL males were unresponsive. MPO males emitted ultrasonic mating vocalizations at high levels while few vocalizations were seen in males of the other brain implant groups. The VMH, AHA, and MPO males urine marked at higher levels than the BSIL males but did not exhibit the high levels of the TSIL males. Mounting was observed only in MPO and TSIL males. Aggression was rare in males from any of the brain implant groups. In the second experiment, the hormone activity of the implants was increased by using testosterone propionate (TP) or a 50% mixture of estradiol (E2) and cholesterol. The six groups were SEPTUMTP, SEPTUME2, MPOTP, MPOE2, TPSIL, and BSIL. The TPSIL males performed all behaviors at male-typical levels while the BSIL males were unresponsive. TP was effective at restoring vocalizations and urine marking only when placed in the MPO; however, E2 was effective at both sites. Again aggression and mounting were less evident in the brain implanted males. In conclusion, implants of T or TP were effective in restoring ultrasonic mating vocalization when placed into the MPO. MPO implants of T and TP were also effective in stimulating urine marking, although VMH and AHA implants also showed some effectiveness. The restorative effects of E2 were not localized which is probably related to the greater hormonal activity of this treatment. Comparisons of the properties of the various brain implants to restore more than one behavior were discussed. | lld:pubmed |
| pubmed-article:1563726 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1563726 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1563726 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1563726 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1563726 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1563726 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1563726 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1563726 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1563726 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1563726 | pubmed:issn | 0018-506X | lld:pubmed |
| pubmed-article:1563726 | pubmed:author | pubmed-author:NybyJJ | lld:pubmed |
| pubmed-article:1563726 | pubmed:author | pubmed-author:BarfieldR JRJ | lld:pubmed |
| pubmed-article:1563726 | pubmed:author | pubmed-author:MatochikJ AJA | lld:pubmed |
| pubmed-article:1563726 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1563726 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:1563726 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1563726 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1563726 | pubmed:pagination | 24-45 | lld:pubmed |
| pubmed-article:1563726 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1563726 | pubmed:meshHeading | pubmed-meshheading:1563726-... | lld:pubmed |
| pubmed-article:1563726 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1563726 | pubmed:articleTitle | Intracranial androgenic and estrogenic stimulation of male-typical behaviors in house mice (Mus domesticus). | lld:pubmed |
| pubmed-article:1563726 | pubmed:affiliation | Department of Psychology, Lehigh University, Bethlehem, PA 18015. | lld:pubmed |
| pubmed-article:1563726 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1563726 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1563726 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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