| pubmed-article:15631942 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15631942 | lifeskim:mentions | umls-concept:C0020542 | lld:lifeskim |
| pubmed-article:15631942 | lifeskim:mentions | umls-concept:C2709248 | lld:lifeskim |
| pubmed-article:15631942 | lifeskim:mentions | umls-concept:C0242606 | lld:lifeskim |
| pubmed-article:15631942 | lifeskim:mentions | umls-concept:C0003765 | lld:lifeskim |
| pubmed-article:15631942 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:15631942 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:15631942 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15631942 | pubmed:dateCreated | 2005-1-5 | lld:pubmed |
| pubmed-article:15631942 | pubmed:abstractText | l-Arginine is substrate for nitric oxide (NO) synthesis and produces pulmonary vasodilatory effects in patients with pulmonary hypertension and in hypoxic animals. We hypothesized that l-arginine would attenuate the increase in oxidative stress and the pulmonary hypertension observed during acute pulmonary embolism (APE). Using an isolated lung perfusion rat model of APE, we examined whether l-arginine (0, 0.1, 0.5, 3, and 10 mmol/L) attenuates the pulmonary hypertension induced by the injection of 6.6 mg/kg of 300 microm Sephadex microspheres into the pulmonary artery. Thiobarbituric acid reactive species (TBA-RS) and nitrite/nitrate (NO(x)) concentrations were measured in lung perfusate to assess oxidative stress and NO production. l-Arginine (0.5, 3, and 10 mmol/L) attenuated (all P<0.05) APE-induced pulmonary hypertension by about 50%. The protective effect of l-arginine was completely reversed by inhibition of NO synthesis with l-NAME (4 mmol/L). In addition, l-arginine (0.5-10 mmol/L) blunted the increase in TBA-RS observed after APE. NO(x) tended to increase only when l-arginine (10 mmol/L) was added to the lung perfusate of non-embolized lungs. Taken together, these findings suggest that l-arginine attenuates APE-induced pulmonary hypertension through antioxidant mechanisms involving increased NO synthesis. | lld:pubmed |
| pubmed-article:15631942 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15631942 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15631942 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15631942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15631942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15631942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15631942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15631942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15631942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15631942 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15631942 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15631942 | pubmed:issn | 1089-8603 | lld:pubmed |
| pubmed-article:15631942 | pubmed:author | pubmed-author:RochaJoão... | lld:pubmed |
| pubmed-article:15631942 | pubmed:author | pubmed-author:GerlachRaquel... | lld:pubmed |
| pubmed-article:15631942 | pubmed:author | pubmed-author:Tanus-SantosJ... | lld:pubmed |
| pubmed-article:15631942 | pubmed:author | pubmed-author:Souza-CostaDe... | lld:pubmed |
| pubmed-article:15631942 | pubmed:author | pubmed-author:ZerbiniTalita... | lld:pubmed |
| pubmed-article:15631942 | pubmed:author | pubmed-author:MetzgerIngrid... | lld:pubmed |
| pubmed-article:15631942 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15631942 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:15631942 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15631942 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15631942 | pubmed:pagination | 9-14 | lld:pubmed |
| pubmed-article:15631942 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15631942 | pubmed:meshHeading | pubmed-meshheading:15631942... | lld:pubmed |
| pubmed-article:15631942 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15631942 | pubmed:articleTitle | l-Arginine attenuates acute pulmonary embolism-induced oxidative stress and pulmonary hypertension. | lld:pubmed |
| pubmed-article:15631942 | pubmed:affiliation | Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil. | lld:pubmed |
| pubmed-article:15631942 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15631942 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:15631942 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15631942 | lld:pubmed |
