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pubmed-article:15620101pubmed:issue10lld:pubmed
pubmed-article:15620101pubmed:dateCreated2004-12-28lld:pubmed
pubmed-article:15620101pubmed:abstractTextFive N10-substituted phenoxazines having different R groups and -Cl substitution at C-2 were found to bind to calf -thymus DNA and plasmid DNA with high affinity as seen from by UV and CD spectroscopy. The effect of phenoxazines on DNA were studied using DNA-ethidium bromide complexes. Upon addition of phenoxazines, the ethidium bromide dissociated from the complex with DNA. The binding of phenoxazines to plasmid PUC18 reduced ethidium bromide binding as seen from the agarose gel electrophoresis. Butyl, and propyl substituted phenoxazines were able to release more ethidium bromide compared with that of acetyl substitution. Addition of phenoxazines also enhanced melting temperature of DNA.lld:pubmed
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pubmed-article:15620101pubmed:statusMEDLINElld:pubmed
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pubmed-article:15620101pubmed:authorpubmed-author:ThimmaiahK...lld:pubmed
pubmed-article:15620101pubmed:authorpubmed-author:ChandramouliK...lld:pubmed
pubmed-article:15620101pubmed:authorpubmed-author:Chandrashekar...lld:pubmed
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pubmed-article:15620101pubmed:volume23lld:pubmed
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pubmed-article:15620101pubmed:pagination1639-56lld:pubmed
pubmed-article:15620101pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15620101pubmed:year2004lld:pubmed
pubmed-article:15620101pubmed:articleTitleInteraction of 2-chloro-N10-substituted phenoxazine with DNA and effect on DNA melting.lld:pubmed
pubmed-article:15620101pubmed:affiliationDepartment of Biochemistry, University of Mysore, Mysore, India.lld:pubmed
pubmed-article:15620101pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15620101pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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