| pubmed-article:15618406 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15618406 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:15618406 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:15618406 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15618406 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:15618406 | lifeskim:mentions | umls-concept:C0021920 | lld:lifeskim |
| pubmed-article:15618406 | lifeskim:mentions | umls-concept:C0035687 | lld:lifeskim |
| pubmed-article:15618406 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:15618406 | lifeskim:mentions | umls-concept:C2247938 | lld:lifeskim |
| pubmed-article:15618406 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:15618406 | lifeskim:mentions | umls-concept:C0441843 | lld:lifeskim |
| pubmed-article:15618406 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15618406 | pubmed:dateCreated | 2005-1-5 | lld:pubmed |
| pubmed-article:15618406 | pubmed:abstractText | Group I and II introns self-splice in vitro, but require proteins for efficient splicing in vivo, to stabilize the catalytically active RNA structure. Recent studies showed that the splicing of some Neurospora crassa mitochondrial group I introns additionally requires a DEAD-box protein, CYT-19, which acts as an RNA chaperone to resolve nonnative structures formed during RNA folding. Here we show that, in Saccharomyces cerevisiae mitochondria, a related DEAD-box protein, Mss116p, is required for the efficient splicing of all group I and II introns, some RNA end-processing reactions, and translation of a subset of mRNAs, and that all these defects can be partially or completely suppressed by the expression of CYT-19. Results for the aI2 group II intron indicate that Mss116p is needed after binding the intron-encoded maturase, likely for the disruption of stable but inactive RNA structures. Our results suggest that both group I and II introns are prone to kinetic traps in RNA folding in vivo and that the splicing of both types of introns may require DEAD-box proteins that function as RNA chaperones. | lld:pubmed |
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| pubmed-article:15618406 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15618406 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15618406 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15618406 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15618406 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15618406 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:15618406 | pubmed:author | pubmed-author:JiangYueY | lld:pubmed |
| pubmed-article:15618406 | pubmed:author | pubmed-author:LambowitzAlan... | lld:pubmed |
| pubmed-article:15618406 | pubmed:author | pubmed-author:PerlmanPhilip... | lld:pubmed |
| pubmed-article:15618406 | pubmed:author | pubmed-author:MohrSabineS | lld:pubmed |
| pubmed-article:15618406 | pubmed:author | pubmed-author:HuangHon-RenH... | lld:pubmed |
| pubmed-article:15618406 | pubmed:author | pubmed-author:RoweClaire... | lld:pubmed |
| pubmed-article:15618406 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15618406 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:15618406 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:15618406 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15618406 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15618406 | pubmed:pagination | 163-8 | lld:pubmed |
| pubmed-article:15618406 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15618406 | pubmed:meshHeading | pubmed-meshheading:15618406... | lld:pubmed |
| pubmed-article:15618406 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15618406 | pubmed:articleTitle | The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function. | lld:pubmed |
| pubmed-article:15618406 | pubmed:affiliation | Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA. | lld:pubmed |
| pubmed-article:15618406 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15618406 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15618406 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:851775 | entrezgene:pubmed | pubmed-article:15618406 | lld:entrezgene |
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