| pubmed-article:15615534 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15615534 | lifeskim:mentions | umls-concept:C0019932 | lld:lifeskim |
| pubmed-article:15615534 | lifeskim:mentions | umls-concept:C0020364 | lld:lifeskim |
| pubmed-article:15615534 | lifeskim:mentions | umls-concept:C1413862 | lld:lifeskim |
| pubmed-article:15615534 | lifeskim:mentions | umls-concept:C1608310 | lld:lifeskim |
| pubmed-article:15615534 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:15615534 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:15615534 | pubmed:issue | 27 | lld:pubmed |
| pubmed-article:15615534 | pubmed:dateCreated | 2004-12-23 | lld:pubmed |
| pubmed-article:15615534 | pubmed:abstractText | A dozen 24-sulfoximine analogues of the hormone 1alpha,25-dihydroxyvitamin D(3) were prepared, differing not only at the stereogenic sulfoximine stereocenter but also at the A-ring. Although these sulfoximines were not active transcriptionally and were only very weakly antiproliferative, some of them are powerful hydroxylase enzyme inhibitors. Specifically, 24-(S)-NH phenyl sulfoximine 3a is an extremely potent CYP24 inhibitor (IC(50) = 7.4 nM) having low calcemic activity. In addition, this compound shows high selectivity toward the CYP24 enzyme in comparison to CYP27A1 (IC(50) > 1000 nM) and CYP27B (IC(50) = 554 nM). | lld:pubmed |
| pubmed-article:15615534 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15615534 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15615534 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15615534 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15615534 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15615534 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15615534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15615534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15615534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15615534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15615534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15615534 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15615534 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15615534 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:15615534 | pubmed:author | pubmed-author:PosnerGary... | lld:pubmed |
| pubmed-article:15615534 | pubmed:author | pubmed-author:KenslerThomas... | lld:pubmed |
| pubmed-article:15615534 | pubmed:author | pubmed-author:PelegSaraS | lld:pubmed |
| pubmed-article:15615534 | pubmed:author | pubmed-author:DolanPatrick... | lld:pubmed |
| pubmed-article:15615534 | pubmed:author | pubmed-author:ChuangSamuel... | lld:pubmed |
| pubmed-article:15615534 | pubmed:author | pubmed-author:KahramanMehme... | lld:pubmed |
| pubmed-article:15615534 | pubmed:author | pubmed-author:SinishtajSand... | lld:pubmed |
| pubmed-article:15615534 | pubmed:author | pubmed-author:KorczakBozena... | lld:pubmed |
| pubmed-article:15615534 | pubmed:author | pubmed-author:SahaUttamU | lld:pubmed |
| pubmed-article:15615534 | pubmed:author | pubmed-author:BernsteinGali... | lld:pubmed |
| pubmed-article:15615534 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15615534 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:15615534 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:15615534 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15615534 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15615534 | pubmed:pagination | 6854-63 | lld:pubmed |
| pubmed-article:15615534 | pubmed:dateRevised | 2008-8-16 | lld:pubmed |
| pubmed-article:15615534 | pubmed:meshHeading | pubmed-meshheading:15615534... | lld:pubmed |
| pubmed-article:15615534 | pubmed:meshHeading | pubmed-meshheading:15615534... | lld:pubmed |
| pubmed-article:15615534 | pubmed:meshHeading | pubmed-meshheading:15615534... | lld:pubmed |
| pubmed-article:15615534 | pubmed:meshHeading | pubmed-meshheading:15615534... | lld:pubmed |
| pubmed-article:15615534 | pubmed:meshHeading | pubmed-meshheading:15615534... | lld:pubmed |
| pubmed-article:15615534 | pubmed:meshHeading | pubmed-meshheading:15615534... | lld:pubmed |
| pubmed-article:15615534 | pubmed:meshHeading | pubmed-meshheading:15615534... | lld:pubmed |
| pubmed-article:15615534 | pubmed:meshHeading | pubmed-meshheading:15615534... | lld:pubmed |
| pubmed-article:15615534 | pubmed:meshHeading | pubmed-meshheading:15615534... | lld:pubmed |
| pubmed-article:15615534 | pubmed:meshHeading | pubmed-meshheading:15615534... | lld:pubmed |
| pubmed-article:15615534 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15615534 | pubmed:articleTitle | Potent, selective and low-calcemic inhibitors of CYP24 hydroxylase: 24-sulfoximine analogues of the hormone 1alpha,25-dihydroxyvitamin D(3). | lld:pubmed |
| pubmed-article:15615534 | pubmed:affiliation | Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, MD 21218, USA. | lld:pubmed |
| pubmed-article:15615534 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15615534 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:15615534 | lld:chembl |
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