| pubmed-article:15614132 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15614132 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
| pubmed-article:15614132 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:15614132 | lifeskim:mentions | umls-concept:C0031154 | lld:lifeskim |
| pubmed-article:15614132 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:15614132 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:15614132 | lifeskim:mentions | umls-concept:C1136254 | lld:lifeskim |
| pubmed-article:15614132 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:15614132 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:15614132 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15614132 | pubmed:dateCreated | 2004-12-22 | lld:pubmed |
| pubmed-article:15614132 | pubmed:abstractText | Interleukin (IL)-12 is a heterodimeric proinflammatory cytokine formed by a p35 and a p40 subunit. To determine the role of IL-12 in abdominal sepsis, p35 gene-deficient (IL-12 knockout, KO) mice and normal wild-type (WT) mice were injected intraperitoneally with Escherichia coli. Peritonitis was associated with a bacterial dose-dependent increase in IL-12 p40 and IL-12 p75 concentrations in peritoneal fluid and plasma. Whereas at 6 h postinfection, IL-12 KO and WT mice displayed similar bacterial counts, at 20 hours IL-12 KO mice had significantly more bacteria in liver homogenates and were more susceptible to progressing to systemic infection. In addition, IL-12 KO mice demonstrated higher levels of proinflammatory cytokines in peritoneal fluid and increased lung and liver injury. IL-12 deficiency did not influence the recruitment of cells to the site of the infection. These data suggest that endogenous IL-12 is involved in the early antibacterial host response during abdominal sepsis. | lld:pubmed |
| pubmed-article:15614132 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15614132 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15614132 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15614132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15614132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15614132 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15614132 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15614132 | pubmed:issn | 1073-2322 | lld:pubmed |
| pubmed-article:15614132 | pubmed:author | pubmed-author:FlorquinSandr... | lld:pubmed |
| pubmed-article:15614132 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:15614132 | pubmed:author | pubmed-author:WeijerSebasti... | lld:pubmed |
| pubmed-article:15614132 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15614132 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:15614132 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15614132 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15614132 | pubmed:pagination | 54-8 | lld:pubmed |
| pubmed-article:15614132 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15614132 | pubmed:meshHeading | pubmed-meshheading:15614132... | lld:pubmed |
| pubmed-article:15614132 | pubmed:meshHeading | pubmed-meshheading:15614132... | lld:pubmed |
| pubmed-article:15614132 | pubmed:meshHeading | pubmed-meshheading:15614132... | lld:pubmed |
| pubmed-article:15614132 | pubmed:meshHeading | pubmed-meshheading:15614132... | lld:pubmed |
| pubmed-article:15614132 | pubmed:meshHeading | pubmed-meshheading:15614132... | lld:pubmed |
| pubmed-article:15614132 | pubmed:meshHeading | pubmed-meshheading:15614132... | lld:pubmed |
| pubmed-article:15614132 | pubmed:meshHeading | pubmed-meshheading:15614132... | lld:pubmed |
| pubmed-article:15614132 | pubmed:meshHeading | pubmed-meshheading:15614132... | lld:pubmed |
| pubmed-article:15614132 | pubmed:meshHeading | pubmed-meshheading:15614132... | lld:pubmed |
| pubmed-article:15614132 | pubmed:meshHeading | pubmed-meshheading:15614132... | lld:pubmed |
| pubmed-article:15614132 | pubmed:meshHeading | pubmed-meshheading:15614132... | lld:pubmed |
| pubmed-article:15614132 | pubmed:meshHeading | pubmed-meshheading:15614132... | lld:pubmed |
| pubmed-article:15614132 | pubmed:meshHeading | pubmed-meshheading:15614132... | lld:pubmed |
| pubmed-article:15614132 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15614132 | pubmed:articleTitle | Endogenous interleukin-12 improves the early antimicrobial host response to murine Escherichia coli peritonitis. | lld:pubmed |
| pubmed-article:15614132 | pubmed:affiliation | Laboratory of Experimental Internal Medicine, Tropical Medicine & AIDS, and University of Amsterdam, Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:15614132 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15614132 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16159 | entrezgene:pubmed | pubmed-article:15614132 | lld:entrezgene |
| entrez-gene:16160 | entrezgene:pubmed | pubmed-article:15614132 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15614132 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15614132 | lld:pubmed |
