| pubmed-article:15612682 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15612682 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:15612682 | lifeskim:mentions | umls-concept:C1707494 | lld:lifeskim |
| pubmed-article:15612682 | lifeskim:mentions | umls-concept:C0920591 | lld:lifeskim |
| pubmed-article:15612682 | pubmed:issue | 51 | lld:pubmed |
| pubmed-article:15612682 | pubmed:dateCreated | 2004-12-22 | lld:pubmed |
| pubmed-article:15612682 | pubmed:abstractText | A successful structure-based design and synthesis of a class of highly potent conformationally constrained Smac mimetics is described. The most potent compound has a Ki value of 25 nM binding to the XIAP BIR3 protein and is 23 times more potent than natural Smac peptides. These potent Smac mimetics can serve as powerful chemical and pharmacological tools to further elucidate the role of Smac and its cellular binding partners in apoptosis regulation and may be developed as a new class of anti-cancer drugs. | lld:pubmed |
| pubmed-article:15612682 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15612682 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15612682 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15612682 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15612682 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15612682 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15612682 | pubmed:issn | 0002-7863 | lld:pubmed |
| pubmed-article:15612682 | pubmed:author | pubmed-author:RollerPeter... | lld:pubmed |
| pubmed-article:15612682 | pubmed:author | pubmed-author:WangShaomengS | lld:pubmed |
| pubmed-article:15612682 | pubmed:author | pubmed-author:XuLiangL | lld:pubmed |
| pubmed-article:15612682 | pubmed:author | pubmed-author:PanHongguangH | lld:pubmed |
| pubmed-article:15612682 | pubmed:author | pubmed-author:YoshiokaYoshi... | lld:pubmed |
| pubmed-article:15612682 | pubmed:author | pubmed-author:SunHaiyingH | lld:pubmed |
| pubmed-article:15612682 | pubmed:author | pubmed-author:KrajewskiKrzy... | lld:pubmed |
| pubmed-article:15612682 | pubmed:author | pubmed-author:Nikolovska-Co... | lld:pubmed |
| pubmed-article:15612682 | pubmed:author | pubmed-author:TomitaYorkY | lld:pubmed |
| pubmed-article:15612682 | pubmed:author | pubmed-author:YangChao-YieC... | lld:pubmed |
| pubmed-article:15612682 | pubmed:author | pubmed-author:LiuMeilanM | lld:pubmed |
| pubmed-article:15612682 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15612682 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:15612682 | pubmed:volume | 126 | lld:pubmed |
| pubmed-article:15612682 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15612682 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15612682 | pubmed:pagination | 16686-7 | lld:pubmed |
| pubmed-article:15612682 | pubmed:dateRevised | 2008-5-14 | lld:pubmed |
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| pubmed-article:15612682 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15612682 | pubmed:articleTitle | Structure-based design of potent, conformationally constrained Smac mimetics. | lld:pubmed |
| pubmed-article:15612682 | pubmed:affiliation | Departments of Internal Medicine and Medicinal Chemistry and Comprehensive Cancer Center, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA. | lld:pubmed |
| pubmed-article:15612682 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15612682 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15612682 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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