| pubmed-article:15611857 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15611857 | lifeskim:mentions | umls-concept:C0014792 | lld:lifeskim |
| pubmed-article:15611857 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:15611857 | lifeskim:mentions | umls-concept:C0814999 | lld:lifeskim |
| pubmed-article:15611857 | lifeskim:mentions | umls-concept:C0004358 | lld:lifeskim |
| pubmed-article:15611857 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:15611857 | lifeskim:mentions | umls-concept:C0205296 | lld:lifeskim |
| pubmed-article:15611857 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15611857 | pubmed:dateCreated | 2005-3-9 | lld:pubmed |
| pubmed-article:15611857 | pubmed:abstractText | Natural antibodies produced by CD5+ B-1 B cells include those with specificity for senescent erythrocytes (anti-BrMRBC, anti-PtC) and for thymocytes (anti-thymocyte autoantibody, ATA). Here we describe work from our laboratories studying two prototypic examples, V(H)11Vkappa9-encoded anti-BrMRBC and V(H)3609Vkappa21c-encoded ATA. Using V(H)11-mu transgenic mice, we discovered that certain natural autoantibodies utilize V(H) genes that are selected against in bone marrow B cell development, but not fetal liver, effectively restricting their generation to fetal/neonatal life. Studies with ATA-mu transgenic mice demonstrated a critical requirement for self antigen in the accumulation of B cells with this specificity and for the production of high levels of serum ATA. Finally, analysis of B cell development in ATA-mu kappa transgenic mice revealed two distinct responses by B cells to expression of this B cell receptor (BCR): most developing B cells in spleen of adult mice were blocked at an immature stage and only escaped apoptosis by editing their BCR to eliminate the ATA specificity; nevertheless, high levels of serum ATA were observed, indicating that some B cells differentiated to antibody-forming cells without altering their specificity. Thus, our studies reveal mechanisms for restricting the generation of B cells producing natural autoantibodies, demonstrate a key positive selection step in their development, and show that most developing B cells in adult mice bearing such specificities fail to reach a mature stage. | lld:pubmed |
| pubmed-article:15611857 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15611857 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15611857 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15611857 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15611857 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15611857 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15611857 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15611857 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15611857 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15611857 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15611857 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15611857 | pubmed:issn | 0344-4325 | lld:pubmed |
| pubmed-article:15611857 | pubmed:author | pubmed-author:HardyRichard... | lld:pubmed |
| pubmed-article:15611857 | pubmed:author | pubmed-author:HayakawaKyoko... | lld:pubmed |
| pubmed-article:15611857 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15611857 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:15611857 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15611857 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15611857 | pubmed:pagination | 363-75 | lld:pubmed |
| pubmed-article:15611857 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:15611857 | pubmed:meshHeading | pubmed-meshheading:15611857... | lld:pubmed |
| pubmed-article:15611857 | pubmed:meshHeading | pubmed-meshheading:15611857... | lld:pubmed |
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| pubmed-article:15611857 | pubmed:meshHeading | pubmed-meshheading:15611857... | lld:pubmed |
| pubmed-article:15611857 | pubmed:meshHeading | pubmed-meshheading:15611857... | lld:pubmed |
| pubmed-article:15611857 | pubmed:meshHeading | pubmed-meshheading:15611857... | lld:pubmed |
| pubmed-article:15611857 | pubmed:meshHeading | pubmed-meshheading:15611857... | lld:pubmed |
| pubmed-article:15611857 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15611857 | pubmed:articleTitle | Development of B cells producing natural autoantibodies to thymocytes and senescent erythrocytes. | lld:pubmed |
| pubmed-article:15611857 | pubmed:affiliation | Division of Basic Sciences, Fox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19111, USA. rr_hardy@fccc.edu | lld:pubmed |
| pubmed-article:15611857 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15611857 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15611857 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:15611857 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:15611857 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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