| pubmed-article:15609081 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15609081 | lifeskim:mentions | umls-concept:C0598800 | lld:lifeskim |
| pubmed-article:15609081 | lifeskim:mentions | umls-concept:C1333018 | lld:lifeskim |
| pubmed-article:15609081 | lifeskim:mentions | umls-concept:C0027686 | lld:lifeskim |
| pubmed-article:15609081 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:15609081 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:15609081 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15609081 | pubmed:dateCreated | 2004-12-20 | lld:pubmed |
| pubmed-article:15609081 | pubmed:abstractText | The NG2 proteoglycan is expressed by nascent pericytes during the early stages of angiogenesis. To investigate the functional role of NG2 in neovascularization, we have compared pathological retinal and corneal angiogenesis in wild type and NG2 null mice. During ischemic retinal neovascularization, ectopic vessels protruding into the vitreous occur twice as frequently in wild type retinas as in NG2 null retinas. In the NG2 knock-out retina, proliferation of both pericytes and endothelial cells is significantly reduced, and the pericyte:endothelial cell ratio falls to 0.24 from the wild type value of 0.86. Similarly, bFGF-induced angiogenesis is reduced more than four-fold in the NG2 null cornea compared to that seen in the wild type retina. Significantly, NG2 antibody is effective in reducing angiogenesis in the wild type cornea, suggesting that the proteoglycan can be an effective target for anti-angiogenic therapy. These experiments therefore demonstrate both the functional importance of NG2 in pericyte development and the feasibility of using pericytes as anti-angiogenic targets. | lld:pubmed |
| pubmed-article:15609081 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15609081 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15609081 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15609081 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15609081 | pubmed:issn | 0969-6970 | lld:pubmed |
| pubmed-article:15609081 | pubmed:author | pubmed-author:OzerdemUgurU | lld:pubmed |
| pubmed-article:15609081 | pubmed:author | pubmed-author:StallcupWilli... | lld:pubmed |
| pubmed-article:15609081 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15609081 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:15609081 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15609081 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15609081 | pubmed:pagination | 269-76 | lld:pubmed |
| pubmed-article:15609081 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15609081 | pubmed:meshHeading | pubmed-meshheading:15609081... | lld:pubmed |
| pubmed-article:15609081 | pubmed:meshHeading | pubmed-meshheading:15609081... | lld:pubmed |
| pubmed-article:15609081 | pubmed:meshHeading | pubmed-meshheading:15609081... | lld:pubmed |
| pubmed-article:15609081 | pubmed:meshHeading | pubmed-meshheading:15609081... | lld:pubmed |
| pubmed-article:15609081 | pubmed:meshHeading | pubmed-meshheading:15609081... | lld:pubmed |
| pubmed-article:15609081 | pubmed:meshHeading | pubmed-meshheading:15609081... | lld:pubmed |
| pubmed-article:15609081 | pubmed:meshHeading | pubmed-meshheading:15609081... | lld:pubmed |
| pubmed-article:15609081 | pubmed:meshHeading | pubmed-meshheading:15609081... | lld:pubmed |
| pubmed-article:15609081 | pubmed:meshHeading | pubmed-meshheading:15609081... | lld:pubmed |
| pubmed-article:15609081 | pubmed:meshHeading | pubmed-meshheading:15609081... | lld:pubmed |
