| pubmed-article:15607976 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15607976 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:15607976 | lifeskim:mentions | umls-concept:C1623134 | lld:lifeskim |
| pubmed-article:15607976 | lifeskim:mentions | umls-concept:C1136031 | lld:lifeskim |
| pubmed-article:15607976 | lifeskim:mentions | umls-concept:C1420123 | lld:lifeskim |
| pubmed-article:15607976 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
| pubmed-article:15607976 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15607976 | pubmed:dateCreated | 2004-12-20 | lld:pubmed |
| pubmed-article:15607976 | pubmed:abstractText | RNAi-mediated heterochromatin assembly in fission yeast requires the RNA-induced transcriptional silencing (RITS) complex and a putative RNA-directed RNA polymerase (Rdp1). Here we show that Rdp1 is associated with two conserved proteins, Hrr1, an RNA helicase, and Cid12, a member of the polyA polymerase family, in a complex that has RNA-directed RNA polymerase activity (RDRC, RNA-directed RNA polymerase complex). RDRC physically interacts with RITS in a manner that requires the Dicer ribonuclease (Dcr1) and the Clr4 histone methyltransferase. Moreover, both complexes are localized to the nucleus and associate with noncoding centromeric RNAs in a Dcr1-dependent manner. In cells lacking Rdp1, Hrr1, or Cid12, RITS complexes are devoid of siRNAs and fail to localize to centromeric DNA repeats to initiate heterochromatin assembly. These findings reveal a physical and functional link between Rdp1 and RITS and suggest that noncoding RNAs provide a platform for siRNA-dependent localization of RNAi complexes to specific chromosome regions. | lld:pubmed |
| pubmed-article:15607976 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15607976 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15607976 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15607976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15607976 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15607976 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15607976 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:15607976 | pubmed:author | pubmed-author:GygiSteven... | lld:pubmed |
| pubmed-article:15607976 | pubmed:author | pubmed-author:GerberScott... | lld:pubmed |
| pubmed-article:15607976 | pubmed:author | pubmed-author:MoazedDaneshD | lld:pubmed |
| pubmed-article:15607976 | pubmed:author | pubmed-author:MotamediMoham... | lld:pubmed |
| pubmed-article:15607976 | pubmed:author | pubmed-author:VerdelAndréA | lld:pubmed |
| pubmed-article:15607976 | pubmed:author | pubmed-author:ColmenaresSer... | lld:pubmed |
| pubmed-article:15607976 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15607976 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:15607976 | pubmed:volume | 119 | lld:pubmed |
| pubmed-article:15607976 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15607976 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15607976 | pubmed:pagination | 789-802 | lld:pubmed |
| pubmed-article:15607976 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15607976 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15607976 | pubmed:articleTitle | Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. | lld:pubmed |
| pubmed-article:15607976 | pubmed:affiliation | Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:15607976 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15607976 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15607976 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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