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| pubmed-article:1560521 | lifeskim:mentions | umls-concept:C0042216 | lld:lifeskim |
| pubmed-article:1560521 | lifeskim:mentions | umls-concept:C0003062 | lld:lifeskim |
| pubmed-article:1560521 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:1560521 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:1560521 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:1560521 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:1560521 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:1560521 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1560521 | pubmed:dateCreated | 1992-5-14 | lld:pubmed |
| pubmed-article:1560521 | pubmed:abstractText | These studies demonstrated that the inbred BALB/c mouse strain can be optimized for the assessment of vaccinia virus virulence, growth, and spread from the site of inoculation and immune protection from a lethal vaccinia virus challenge. The studies established that manipulation of the vaccinia virus genome generated mutants exhibiting a wide range of attenuated phenotypes. The nine NYCBH vaccinia virus mutants had intracranial 50% lethal doses that ranged from 2 to greater than 7 log10 units. The decreased neurovirulence was due to decreased replication in brain tissue. Three mutants had a decreased ability to disseminate to the lungs, brains, livers, and spleens of mice after intranasal infection. One mutant had a decreased transmission from mice infected by tail scarification to naive cage mates. Although the mutants, with one exception, grew to wild-type titers in cell culture, they showed a growth potential on the scarified skin of mice that was dramatically different from that of the wild-type virus. Consequently, all of the mutants had significantly compromised immunogenicities at low virus immunization doses compared with that of the wild-type virus. Conversely, at high immunization doses most mutants could induce an immune response similar to that of the wild-type virus. Three Wyeth vaccine strain mutants were also studied. Whereas the thymidine kinase, ribonucleotide reductase, and hemagglutinin mutants had a reduced virulence (50% lethal dose), only the thymidine kinase mutant retained its immunogenicity. | lld:pubmed |
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| pubmed-article:1560521 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1560521 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1560521 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1560521 | pubmed:month | May | lld:pubmed |
| pubmed-article:1560521 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:1560521 | pubmed:author | pubmed-author:LeeM SMS | lld:pubmed |
| pubmed-article:1560521 | pubmed:author | pubmed-author:RobertsB EBE | lld:pubmed |
| pubmed-article:1560521 | pubmed:author | pubmed-author:SmithK AKA | lld:pubmed |
| pubmed-article:1560521 | pubmed:author | pubmed-author:CohenL KLK | lld:pubmed |
| pubmed-article:1560521 | pubmed:author | pubmed-author:PayneL GLG | lld:pubmed |
| pubmed-article:1560521 | pubmed:author | pubmed-author:RootJ JJJ | lld:pubmed |
| pubmed-article:1560521 | pubmed:author | pubmed-author:CormierNN | lld:pubmed |
| pubmed-article:1560521 | pubmed:author | pubmed-author:McGuiganL CLC | lld:pubmed |
| pubmed-article:1560521 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1560521 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:1560521 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1560521 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1560521 | pubmed:pagination | 2617-30 | lld:pubmed |
| pubmed-article:1560521 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1560521 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1560521 | pubmed:articleTitle | Molecular attenuation of vaccinia virus: mutant generation and animal characterization. | lld:pubmed |
| pubmed-article:1560521 | pubmed:affiliation | Applied bioTechnology, Inc., Cambridge, Massachusetts 02142. | lld:pubmed |
| pubmed-article:1560521 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1560521 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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