| pubmed-article:15603920 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15603920 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:15603920 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:15603920 | lifeskim:mentions | umls-concept:C0059735 | lld:lifeskim |
| pubmed-article:15603920 | lifeskim:mentions | umls-concept:C0207509 | lld:lifeskim |
| pubmed-article:15603920 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:15603920 | lifeskim:mentions | umls-concept:C0025270 | lld:lifeskim |
| pubmed-article:15603920 | lifeskim:mentions | umls-concept:C0919425 | lld:lifeskim |
| pubmed-article:15603920 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15603920 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15603920 | pubmed:dateCreated | 2004-12-17 | lld:pubmed |
| pubmed-article:15603920 | pubmed:abstractText | The effects of menadione on activities and expression of cytochrome P450 (CYP) 1A subfamily (CYP1A) isozymes in rat hepatic tissue were examined. When rats were treated orally with 15 mg/kg menadione for 4 days, the elevation of hepatic CYP1A1/1A2 specific activities in microsomal preparations was detected with approximately 5.4- and 2.5-fold increase over control values for ethoxyresorufin-O-deethylase (EROD, CYP1A1) and methoxyresorufin-O-demethylase (MROD, CYP1A2) activities, respectively. CYP1A1 and CYP1A2 mRNA levels in the liver of menadione-treated rats were approximately 11.8- and 1.8-fold higher than in controls, respectively, whereas the expression of the CYP1A regulatory proteins aryl hydrocarbon-receptor (AhR) and AhR nuclear translocator (Arnt) was not changed at the mRNA level. The result of this study demonstrates that menadione induces CYP1A1/1A2 expression in vivo through either transcriptional activation and/or mRNA stabilization. | lld:pubmed |
| pubmed-article:15603920 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15603920 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15603920 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15603920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15603920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15603920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15603920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15603920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15603920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15603920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15603920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15603920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15603920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15603920 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15603920 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15603920 | pubmed:issn | 0378-4274 | lld:pubmed |
| pubmed-article:15603920 | pubmed:author | pubmed-author:LyakhovichV... | lld:pubmed |
| pubmed-article:15603920 | pubmed:author | pubmed-author:GrishanovaA... | lld:pubmed |
| pubmed-article:15603920 | pubmed:author | pubmed-author:SidorovaY AYA | lld:pubmed |
| pubmed-article:15603920 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15603920 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15603920 | pubmed:volume | 155 | lld:pubmed |
| pubmed-article:15603920 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15603920 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15603920 | pubmed:pagination | 253-8 | lld:pubmed |
| pubmed-article:15603920 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15603920 | pubmed:meshHeading | pubmed-meshheading:15603920... | lld:pubmed |
| pubmed-article:15603920 | pubmed:meshHeading | pubmed-meshheading:15603920... | lld:pubmed |
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| pubmed-article:15603920 | pubmed:meshHeading | pubmed-meshheading:15603920... | lld:pubmed |
| pubmed-article:15603920 | pubmed:meshHeading | pubmed-meshheading:15603920... | lld:pubmed |
| pubmed-article:15603920 | pubmed:meshHeading | pubmed-meshheading:15603920... | lld:pubmed |
| pubmed-article:15603920 | pubmed:meshHeading | pubmed-meshheading:15603920... | lld:pubmed |
| pubmed-article:15603920 | pubmed:meshHeading | pubmed-meshheading:15603920... | lld:pubmed |
| pubmed-article:15603920 | pubmed:meshHeading | pubmed-meshheading:15603920... | lld:pubmed |
| pubmed-article:15603920 | pubmed:meshHeading | pubmed-meshheading:15603920... | lld:pubmed |
| pubmed-article:15603920 | pubmed:meshHeading | pubmed-meshheading:15603920... | lld:pubmed |
| pubmed-article:15603920 | pubmed:meshHeading | pubmed-meshheading:15603920... | lld:pubmed |
| pubmed-article:15603920 | pubmed:meshHeading | pubmed-meshheading:15603920... | lld:pubmed |
| pubmed-article:15603920 | pubmed:meshHeading | pubmed-meshheading:15603920... | lld:pubmed |
| pubmed-article:15603920 | pubmed:meshHeading | pubmed-meshheading:15603920... | lld:pubmed |
| pubmed-article:15603920 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15603920 | pubmed:articleTitle | Rat hepatic CYP1A1 and CYP1A2 induction by menadione. | lld:pubmed |
| pubmed-article:15603920 | pubmed:affiliation | Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Medical Sciences, Timakova str. 2, Novosibirsk 630090, Russia. ysidorova@soramn.ru | lld:pubmed |
| pubmed-article:15603920 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15603920 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
