| pubmed-article:15596716 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15596716 | lifeskim:mentions | umls-concept:C0206558 | lld:lifeskim |
| pubmed-article:15596716 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:15596716 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15596716 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:15596716 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:15596716 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
| pubmed-article:15596716 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:15596716 | pubmed:issue | 52 | lld:pubmed |
| pubmed-article:15596716 | pubmed:dateCreated | 2004-12-29 | lld:pubmed |
| pubmed-article:15596716 | pubmed:abstractText | The U(L)41 protein of herpes simplex virus 1 has been reported to mediate the degradation of both viral and cellular mRNAs. Extensive studies on beta-actin and some viral mRNAs were consonant with this conclusion. In earlier studies, we reported that the U(L)41-dependent degradation of cellular mRNAs up-regulated after infection was selective. One class of the up-regulated mRNAs, exemplified by the stress-inducible immediate-early 1 mRNA, is deadenylated, 3' to 5' degraded and is not translated. Another class of up-regulated mRNAs, exemplified by GADD45beta, does not undergo this pattern of degradation and is translated. A puzzling feature of the earlier results is that the amounts of up-regulated mRNAs accumulating in the cytoplasm of DeltaU(L)41 mutant virus-infected cells was lower than in WT virus-infected cells, a contradiction, inasmuch as if the rates of accumulation were identical and degradation of the mRNAs were higher in WT virus-infected cells, the steady-state levels should have been higher in DeltaU(L)41 mutant virus-infected cells. In this report, we show that in DeltaU(L)41 mutant virus-infected cells, the rates of degradation of the stress-inducible immediate-early response gene 1 and other up-regulated mRNAs are approximately the same as those observed in mock-infected cells and are faster than in WT virus-infected cells. This is contrary to the observed U(L)41-dependent degradation of beta-actin and other mRNAs. The U(L)41 protein thus mediates two functions, i.e., it mediates rapid degradation of some mRNAs exemplified by beta-actin and stabilizes or delays the degradation of other mRNAs exemplified by GADD45beta, tristetraprolin, etc. A model unifying both activities of the U(L)41 protein is presented. | lld:pubmed |
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| pubmed-article:15596716 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15596716 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15596716 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15596716 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15596716 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:15596716 | pubmed:author | pubmed-author:RoizmanBernar... | lld:pubmed |
| pubmed-article:15596716 | pubmed:author | pubmed-author:TaddeoBrunell... | lld:pubmed |
| pubmed-article:15596716 | pubmed:author | pubmed-author:EsclatineAudr... | lld:pubmed |
| pubmed-article:15596716 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15596716 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:15596716 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:15596716 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15596716 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15596716 | pubmed:pagination | 18165-70 | lld:pubmed |
| pubmed-article:15596716 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15596716 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15596716 | pubmed:articleTitle | The UL41 protein of herpes simplex virus mediates selective stabilization or degradation of cellular mRNAs. | lld:pubmed |
| pubmed-article:15596716 | pubmed:affiliation | The Marjorie Kovler Viral Oncology Laboratories, University of Chicago, Chicago, IL 60637, USA. | lld:pubmed |
| pubmed-article:15596716 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15596716 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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