| pubmed-article:15596543 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15596543 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15596543 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:15596543 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:15596543 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:15596543 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:15596543 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:15596543 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:15596543 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:15596543 | lifeskim:mentions | umls-concept:C1418275 | lld:lifeskim |
| pubmed-article:15596543 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15596543 | pubmed:dateCreated | 2004-12-21 | lld:pubmed |
| pubmed-article:15596543 | pubmed:abstractText | The mechanism by which the beta-cell transcription factor Pax4 influences cell function/mass was studied in rat and human islets of Langerhans. Pax4 transcripts were detected in adult rat islets, and levels were induced by the mitogens activin A and betacellulin. Wortmannin suppressed betacellulin-induced Pax4 expression, implicating the phosphatidylinositol 3-kinase signaling pathway. Adenoviral overexpression of Pax4 caused a 3.5-fold increase in beta-cell proliferation with a concomitant 1.9-, 4-, and 5-fold increase in Bcl-xL (antiapoptotic), c-myc, and Id2 mRNA levels, respectively. Accordingly, Pax4 transactivated the Bcl-xL and c-myc promoters, whereas its diabetes-linked mutant was less efficient. Bcl-xL activity resulted in altered mitochondrial calcium levels and ATP production, explaining impaired glucose-induced insulin secretion in transduced islets. Infection of human islets with an inducible adenoviral Pax4 construct caused proliferation and protection against cytokine-evoked apoptosis, whereas the mutant was less effective. We propose that Pax4 is implicated in beta-cell plasticity through the activation of c-myc and potentially protected from apoptosis through Bcl-xL gene expression. | lld:pubmed |
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| pubmed-article:15596543 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15596543 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15596543 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15596543 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15596543 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15596543 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:15596543 | pubmed:author | pubmed-author:WollheimClaes... | lld:pubmed |
| pubmed-article:15596543 | pubmed:author | pubmed-author:GauthierBenoi... | lld:pubmed |
| pubmed-article:15596543 | pubmed:author | pubmed-author:Biason-Lauber... | lld:pubmed |
| pubmed-article:15596543 | pubmed:author | pubmed-author:St-OngeLucL | lld:pubmed |
| pubmed-article:15596543 | pubmed:author | pubmed-author:FranklinIsobe... | lld:pubmed |
| pubmed-article:15596543 | pubmed:author | pubmed-author:BrunThierryT | lld:pubmed |
| pubmed-article:15596543 | pubmed:author | pubmed-author:SchoenleEugen... | lld:pubmed |
| pubmed-article:15596543 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15596543 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:15596543 | pubmed:volume | 167 | lld:pubmed |
| pubmed-article:15596543 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15596543 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15596543 | pubmed:pagination | 1123-35 | lld:pubmed |
| pubmed-article:15596543 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15596543 | pubmed:meshHeading | pubmed-meshheading:15596543... | lld:pubmed |
| pubmed-article:15596543 | pubmed:meshHeading | pubmed-meshheading:15596543... | lld:pubmed |
| pubmed-article:15596543 | pubmed:meshHeading | pubmed-meshheading:15596543... | lld:pubmed |
