| pubmed-article:1558805 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1558805 | lifeskim:mentions | umls-concept:C0678222 | lld:lifeskim |
| pubmed-article:1558805 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:1558805 | lifeskim:mentions | umls-concept:C0237881 | lld:lifeskim |
| pubmed-article:1558805 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:1558805 | lifeskim:mentions | umls-concept:C0220901 | lld:lifeskim |
| pubmed-article:1558805 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:1558805 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:1558805 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1558805 | pubmed:dateCreated | 1992-5-12 | lld:pubmed |
| pubmed-article:1558805 | pubmed:abstractText | We previously reported that the expression on the primary tumour of the antigen CaMBr8 was related to a short survival, attributable either to higher tumour aggressiveness or a poor response to oophorectomy. To further verify the CaMBr8 prognostic value, we analysed retrospectively 862 breast cancer patients with a 19 year follow-up. In this series, CaMBr8 expression was found to be associated to some negative prognostic factors (premenopausal status, lymphnode invasion, a high number of mitosis and HER-2/neu oncoprotein expression), but had no influence on the patients' survival. Direct association with a poor prognosis was only evident in patients with lobular or mixed breast carcinoma, which however represent only a small fraction of the total breast cancers. Another possibility was that CaMBr8 could identify a subgroup of patients which did not respond to hormone therapy. To verify this hypothesis we evaluated on a second series of 116 patients the relationship between CaMBr8 expression and hormone-receptor levels. A negative association emerged which was also observed in vitro in the human breast cancer line MCF-7 treated with Sodium Butyrate, a differentiation inducer, which reduced hormone-receptor levels and increased CaMBr8 expression. In conclusion, the longer survival of CaMBr8 negative tumour patients observed in the initial study, was probably related to a better response to oophorectomy, due to the hormone-receptor level of their tumours. | lld:pubmed |
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| pubmed-article:1558805 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1558805 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1558805 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1558805 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1558805 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1558805 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1558805 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:1558805 | pubmed:author | pubmed-author:CanevariSS | lld:pubmed |
| pubmed-article:1558805 | pubmed:author | pubmed-author:AndreolaSS | lld:pubmed |
| pubmed-article:1558805 | pubmed:author | pubmed-author:MénardSS | lld:pubmed |
| pubmed-article:1558805 | pubmed:author | pubmed-author:Di FronzoGG | lld:pubmed |
| pubmed-article:1558805 | pubmed:author | pubmed-author:CascinelliNN | lld:pubmed |
| pubmed-article:1558805 | pubmed:author | pubmed-author:PerroneFF | lld:pubmed |
| pubmed-article:1558805 | pubmed:author | pubmed-author:BufalinoRR | lld:pubmed |
| pubmed-article:1558805 | pubmed:author | pubmed-author:BazziniPP | lld:pubmed |
| pubmed-article:1558805 | pubmed:author | pubmed-author:FacherisPP | lld:pubmed |
| pubmed-article:1558805 | pubmed:author | pubmed-author:ColzaniEE | lld:pubmed |
| pubmed-article:1558805 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1558805 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:1558805 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1558805 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:1558805 | pubmed:pagination | 466-70 | lld:pubmed |
| pubmed-article:1558805 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1558805 | pubmed:meshHeading | pubmed-meshheading:1558805-... | lld:pubmed |
| pubmed-article:1558805 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1558805 | pubmed:articleTitle | Study of the biological and prognostic significance of the antigen CaMBr8 on breast carcinoma. | lld:pubmed |
| pubmed-article:1558805 | pubmed:affiliation | Experimental Oncology E, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy. | lld:pubmed |
| pubmed-article:1558805 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1558805 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1558805 | lld:pubmed |
