| pubmed-article:15583118 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15583118 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
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| pubmed-article:15583118 | lifeskim:mentions | umls-concept:C0170657 | lld:lifeskim |
| pubmed-article:15583118 | lifeskim:mentions | umls-concept:C0024517 | lld:lifeskim |
| pubmed-article:15583118 | lifeskim:mentions | umls-concept:C0004271 | lld:lifeskim |
| pubmed-article:15583118 | lifeskim:mentions | umls-concept:C0439793 | lld:lifeskim |
| pubmed-article:15583118 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15583118 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:15583118 | lifeskim:mentions | umls-concept:C0444706 | lld:lifeskim |
| pubmed-article:15583118 | lifeskim:mentions | umls-concept:C0032743 | lld:lifeskim |
| pubmed-article:15583118 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15583118 | pubmed:dateCreated | 2004-12-7 | lld:pubmed |
| pubmed-article:15583118 | pubmed:abstractText | Although brain serotonin transporter (5-HTT) density has been investigated in subjects with a history of major depressive episodes (MDE), there has never been an investigation of brain 5-HTT during a current MDE. Brain 5-HTT binding potential (BP) may have an important role during MDE due to major depressive disorder, because the 5-HTT regulates extracellular 5-HT. The BP is an index of receptor density. Carbon 11-labeled 3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB) positron emission tomography (PET) is the first brain imaging technique that can measure the 5-HTT BP in cortical and subcortical brain regions in vivo. The purposes of this study were to investigate 5-HTT BP during MDE and to determine the relationship between 5-HTT BP and negativistic dysfunctional attitudes during MDE. Dysfunctional attitudes are negatively biased assumptions and beliefs regarding oneself, the world, and the future. Our recent publication of increased serotonin2 BP in MDE with severely negativistic dysfunctional attitudes suggests that this subgroup of MDE subjects has very low levels of extracellular serotonin. | lld:pubmed |
| pubmed-article:15583118 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15583118 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15583118 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:15583118 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15583118 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15583118 | pubmed:issn | 0003-990X | lld:pubmed |
| pubmed-article:15583118 | pubmed:author | pubmed-author:HouleSylvainS | lld:pubmed |
| pubmed-article:15583118 | pubmed:author | pubmed-author:WilsonAlan... | lld:pubmed |
| pubmed-article:15583118 | pubmed:author | pubmed-author:KennedyJamesJ | lld:pubmed |
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| pubmed-article:15583118 | pubmed:author | pubmed-author:MeyerJeffrey... | lld:pubmed |
| pubmed-article:15583118 | pubmed:author | pubmed-author:SagratiSandra... | lld:pubmed |
| pubmed-article:15583118 | pubmed:author | pubmed-author:CarellaAnnaA | lld:pubmed |
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| pubmed-article:15583118 | pubmed:author | pubmed-author:GouldingVerde... | lld:pubmed |
| pubmed-article:15583118 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15583118 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:15583118 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15583118 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15583118 | pubmed:pagination | 1271-9 | lld:pubmed |
| pubmed-article:15583118 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15583118 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15583118 | pubmed:articleTitle | Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: effects of major depressive episodes and severity of dysfunctional attitudes. | lld:pubmed |
| pubmed-article:15583118 | pubmed:affiliation | Vivian M. Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada. jeff.meyer@camhpet.ca | lld:pubmed |
| pubmed-article:15583118 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15583118 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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