| pubmed-article:15579484 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15579484 | lifeskim:mentions | umls-concept:C0667830 | lld:lifeskim |
| pubmed-article:15579484 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:15579484 | lifeskim:mentions | umls-concept:C0024623 | lld:lifeskim |
| pubmed-article:15579484 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:15579484 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:15579484 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:15579484 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15579484 | pubmed:dateCreated | 2005-2-24 | lld:pubmed |
| pubmed-article:15579484 | pubmed:abstractText | Aspirin-induced apoptosis is one of the important mechanisms for its antitumour effect against gastric cancer. We aimed at investigating the involvement of bcl-2 family members in the apoptotic pathway in gastric cancer. Gastric cancer cell line AGS and MKN-45 were observed as to cell growth inhibition and induction of apoptosis in response to treatment with aspirin. Cell proliferation was measured by MTT assay. Apoptosis was determined by 4'-6-diamidino-2-phenylindole staining. Protein expression was determined by western blotting. We showed that aspirin activated caspase-8, caspase-9 and capase-3, cleaved and translocated Bid, induced a conformational change in and translocation of Bax and cytochrome c release. In addition, suppression of caspase-8 with the specific inhibitor z-IETD-fmk, as well as the pan-caspase inhibitor z-VAD-fmk, prevented Bid cleavage and subsequent apoptosis. The caspase inhibitors failed to abolish the effects on Bax activation. In conclusion, our results identify a role of caspase-8/Bid and activation of Bax as a novel mechanism for aspirin-induced apoptosis in gastric cancer. | lld:pubmed |
| pubmed-article:15579484 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15579484 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15579484 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15579484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15579484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15579484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15579484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15579484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15579484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15579484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15579484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15579484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15579484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15579484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15579484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15579484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15579484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15579484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15579484 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15579484 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15579484 | pubmed:issn | 0143-3334 | lld:pubmed |
| pubmed-article:15579484 | pubmed:author | pubmed-author:CaseN BNB | lld:pubmed |
| pubmed-article:15579484 | pubmed:author | pubmed-author:YangYiY | lld:pubmed |
| pubmed-article:15579484 | pubmed:author | pubmed-author:RIBIAA | lld:pubmed |
| pubmed-article:15579484 | pubmed:author | pubmed-author:WongBenjamin... | lld:pubmed |
| pubmed-article:15579484 | pubmed:author | pubmed-author:HeHuaH | lld:pubmed |
| pubmed-article:15579484 | pubmed:author | pubmed-author:LamShiu KumSK | lld:pubmed |
| pubmed-article:15579484 | pubmed:author | pubmed-author:WongWai ManWM | lld:pubmed |
| pubmed-article:15579484 | pubmed:author | pubmed-author:YuenMan... | lld:pubmed |
| pubmed-article:15579484 | pubmed:author | pubmed-author:ChanAnnie O... | lld:pubmed |
| pubmed-article:15579484 | pubmed:author | pubmed-author:LinMarie C... | lld:pubmed |
| pubmed-article:15579484 | pubmed:author | pubmed-author:XiaHarry H... | lld:pubmed |
| pubmed-article:15579484 | pubmed:author | pubmed-author:TuShui PingSP | lld:pubmed |
| pubmed-article:15579484 | pubmed:author | pubmed-author:KungHsiang... | lld:pubmed |
| pubmed-article:15579484 | pubmed:author | pubmed-author:WangJi DeJD | lld:pubmed |
| pubmed-article:15579484 | pubmed:author | pubmed-author:LiuXin... | lld:pubmed |
| pubmed-article:15579484 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15579484 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:15579484 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15579484 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15579484 | pubmed:pagination | 541-6 | lld:pubmed |
| pubmed-article:15579484 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15579484 | pubmed:meshHeading | pubmed-meshheading:15579484... | lld:pubmed |
| pubmed-article:15579484 | pubmed:meshHeading | pubmed-meshheading:15579484... | lld:pubmed |
| pubmed-article:15579484 | pubmed:meshHeading | pubmed-meshheading:15579484... | lld:pubmed |
| pubmed-article:15579484 | pubmed:meshHeading | pubmed-meshheading:15579484... | lld:pubmed |
| pubmed-article:15579484 | pubmed:meshHeading | pubmed-meshheading:15579484... | lld:pubmed |
| pubmed-article:15579484 | pubmed:meshHeading | pubmed-meshheading:15579484... | lld:pubmed |
| pubmed-article:15579484 | pubmed:meshHeading | pubmed-meshheading:15579484... | lld:pubmed |
| pubmed-article:15579484 | pubmed:meshHeading | pubmed-meshheading:15579484... | lld:pubmed |
| pubmed-article:15579484 | pubmed:meshHeading | pubmed-meshheading:15579484... | lld:pubmed |
| pubmed-article:15579484 | pubmed:meshHeading | pubmed-meshheading:15579484... | lld:pubmed |
| pubmed-article:15579484 | pubmed:meshHeading | pubmed-meshheading:15579484... | lld:pubmed |
| pubmed-article:15579484 | pubmed:meshHeading | pubmed-meshheading:15579484... | lld:pubmed |
| pubmed-article:15579484 | pubmed:meshHeading | pubmed-meshheading:15579484... | lld:pubmed |
| pubmed-article:15579484 | pubmed:meshHeading | pubmed-meshheading:15579484... | lld:pubmed |
| pubmed-article:15579484 | pubmed:meshHeading | pubmed-meshheading:15579484... | lld:pubmed |
| pubmed-article:15579484 | pubmed:meshHeading | pubmed-meshheading:15579484... | lld:pubmed |
| pubmed-article:15579484 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15579484 | pubmed:articleTitle | Activation of the caspase-8/Bid and Bax pathways in aspirin-induced apoptosis in gastric cancer. | lld:pubmed |
| pubmed-article:15579484 | pubmed:affiliation | Department of Gastroenterology, First Hospital, Peking University, Beijing, People's Republic of China. | lld:pubmed |
| pubmed-article:15579484 | pubmed:publicationType | Journal Article | lld:pubmed |
