| pubmed-article:15568018 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15568018 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:15568018 | lifeskim:mentions | umls-concept:C1099354 | lld:lifeskim |
| pubmed-article:15568018 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:15568018 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15568018 | lifeskim:mentions | umls-concept:C0678613 | lld:lifeskim |
| pubmed-article:15568018 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15568018 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15568018 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15568018 | pubmed:dateCreated | 2004-12-7 | lld:pubmed |
| pubmed-article:15568018 | pubmed:abstractText | Here we demonstrate that an inducible anti-HIV short hairpin RNA (shRNA) expressed from a Pol II promoter inhibits HIV-1 gene expression in mammalian cells. Our strategy is based on a promoter system in which the HIV-1 LTR is fused to the Drosophila hsp70 minimal heat shock promoter. This system is inducible by HIV-1 TAT, which functions in a negative feedback loop to activate transcription of an shRNA directed against HIV-1 rev. Upon induction the shRNA is processed to an siRNA that guides inhibition of HIV replication in cultured T-lymphocytes and hematopoietic stem cell-derived monocytes. The fusion promoter system may be safer than drug-inducible systems for shRNA-mediated gene therapy against HIV as the shRNAs are only expressed following HIV infection. | lld:pubmed |
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| pubmed-article:15568018 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15568018 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15568018 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15568018 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15568018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15568018 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15568018 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15568018 | pubmed:issn | 1087-0156 | lld:pubmed |
| pubmed-article:15568018 | pubmed:author | pubmed-author:LiMing-JieMJ | lld:pubmed |
| pubmed-article:15568018 | pubmed:author | pubmed-author:EhsaniAliA | lld:pubmed |
| pubmed-article:15568018 | pubmed:author | pubmed-author:RossiJohn JJJ | lld:pubmed |
| pubmed-article:15568018 | pubmed:author | pubmed-author:UnwallaHoshan... | lld:pubmed |
| pubmed-article:15568018 | pubmed:author | pubmed-author:KimJames DJD | lld:pubmed |
| pubmed-article:15568018 | pubmed:author | pubmed-author:LiHai TangHT | lld:pubmed |
| pubmed-article:15568018 | pubmed:author | pubmed-author:AlluinJessica... | lld:pubmed |
| pubmed-article:15568018 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15568018 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:15568018 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15568018 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15568018 | pubmed:pagination | 1573-8 | lld:pubmed |
| pubmed-article:15568018 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:15568018 | pubmed:meshHeading | pubmed-meshheading:15568018... | lld:pubmed |
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| pubmed-article:15568018 | pubmed:meshHeading | pubmed-meshheading:15568018... | lld:pubmed |
| pubmed-article:15568018 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15568018 | pubmed:articleTitle | Negative feedback inhibition of HIV-1 by TAT-inducible expression of siRNA. | lld:pubmed |
| pubmed-article:15568018 | pubmed:publicationType | Letter | lld:pubmed |
| pubmed-article:15568018 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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