| pubmed-article:15567157 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15567157 | lifeskim:mentions | umls-concept:C0004057 | lld:lifeskim |
| pubmed-article:15567157 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:15567157 | lifeskim:mentions | umls-concept:C0376448 | lld:lifeskim |
| pubmed-article:15567157 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:15567157 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15567157 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15567157 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15567157 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15567157 | pubmed:dateCreated | 2004-11-29 | lld:pubmed |
| pubmed-article:15567157 | pubmed:abstractText | beta-Catenin has been implicated in leukemic cell proliferation. We compared the effects of aspirin (ASA) and the ortho, meta, and para positional isomers of NO-donating aspirin (NO-ASA) on cell growth and beta-catenin expression in human Jurkat T leukemic cells. Cell growth inhibition was strong: IC(50) for p-, o-, and m- were 20+/-1.6 (mean+/-SEM), 15+/-1.5, and 200+/-12 microM, respectively, in contrast to that of ASA (3200+/-375 microM). The para isomer of NO-ASA degraded beta-catenin in a dose- and time-dependent manner coinciding with increasing expression of activated caspase-3. The caspase inhibitor ZVAD blocked beta-catenin cleavage by p-NO-ASA and partially reversed cell growth inhibition by p-NO-ASA but not that by ASA. A denitrated analog of p-NO-ASA did not degrade beta-catenin indicating the importance of the NO-donating moiety. Our findings suggest that NO-ASA merits further study as an agent against leukemia. | lld:pubmed |
| pubmed-article:15567157 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15567157 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15567157 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15567157 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15567157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15567157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15567157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15567157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15567157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15567157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15567157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15567157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15567157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15567157 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15567157 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15567157 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:15567157 | pubmed:author | pubmed-author:NathNiharikaN | lld:pubmed |
| pubmed-article:15567157 | pubmed:author | pubmed-author:RigasBasilB | lld:pubmed |
| pubmed-article:15567157 | pubmed:author | pubmed-author:KashfiKhosrow... | lld:pubmed |
| pubmed-article:15567157 | pubmed:author | pubmed-author:LabazeGeorges... | lld:pubmed |
| pubmed-article:15567157 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15567157 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:15567157 | pubmed:volume | 326 | lld:pubmed |
| pubmed-article:15567157 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15567157 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15567157 | pubmed:pagination | 93-9 | lld:pubmed |
| pubmed-article:15567157 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15567157 | pubmed:meshHeading | pubmed-meshheading:15567157... | lld:pubmed |
| pubmed-article:15567157 | pubmed:meshHeading | pubmed-meshheading:15567157... | lld:pubmed |
| pubmed-article:15567157 | pubmed:meshHeading | pubmed-meshheading:15567157... | lld:pubmed |
| pubmed-article:15567157 | pubmed:meshHeading | pubmed-meshheading:15567157... | lld:pubmed |
| pubmed-article:15567157 | pubmed:meshHeading | pubmed-meshheading:15567157... | lld:pubmed |
| pubmed-article:15567157 | pubmed:meshHeading | pubmed-meshheading:15567157... | lld:pubmed |
| pubmed-article:15567157 | pubmed:meshHeading | pubmed-meshheading:15567157... | lld:pubmed |
| pubmed-article:15567157 | pubmed:meshHeading | pubmed-meshheading:15567157... | lld:pubmed |
| pubmed-article:15567157 | pubmed:meshHeading | pubmed-meshheading:15567157... | lld:pubmed |
| pubmed-article:15567157 | pubmed:meshHeading | pubmed-meshheading:15567157... | lld:pubmed |
| pubmed-article:15567157 | pubmed:meshHeading | pubmed-meshheading:15567157... | lld:pubmed |
| pubmed-article:15567157 | pubmed:meshHeading | pubmed-meshheading:15567157... | lld:pubmed |
| pubmed-article:15567157 | pubmed:meshHeading | pubmed-meshheading:15567157... | lld:pubmed |
| pubmed-article:15567157 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15567157 | pubmed:articleTitle | NO-donating aspirin inhibits the growth of leukemic Jurkat cells and modulates beta-catenin expression. | lld:pubmed |
| pubmed-article:15567157 | pubmed:affiliation | Department of Physiology and Pharmacology, City University of New York Medical School, New York, NY 10031, USA. | lld:pubmed |
| pubmed-article:15567157 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15567157 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15567157 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15567157 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15567157 | lld:pubmed |
