| pubmed-article:15567083 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15567083 | lifeskim:mentions | umls-concept:C0079399 | lld:lifeskim |
| pubmed-article:15567083 | lifeskim:mentions | umls-concept:C0036341 | lld:lifeskim |
| pubmed-article:15567083 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15567083 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15567083 | pubmed:dateCreated | 2004-11-29 | lld:pubmed |
| pubmed-article:15567083 | pubmed:abstractText | Insula is a multimodal sensory integration region that acts as a gateway between somatosensory areas and limbic structures such as amygdala. Only a handful of region of interest (ROI) studies have suggested insular volume reduction in patients with schizophrenia but none have documented a gender effect on the volume of this structure. The authors used magnetic resonance images to measure insular volumes in previously untreated patients with first-episode schizophrenia (N=30) relative to those of healthy comparison subjects (N=30). Correlations with symptom severity were carried out. Intracranial volume was used as a covariate in the analysis. Female patients (N=15) had significantly reduced right insular volume relative to healthy female comparison subjects (p<0.05). On preliminary analysis, the right and left insular volumes in female patients had significant negative correlations with the positive symptoms scores (p<0.05), but not on correcting for multiple comparisons. Insula is developmentally and phylogenetically a watershed region where the more primitive allocortex transitions into the more developed isocortex. Thus its role as a substrate of neurodevelopmental hypothesis in schizophrenia and the interplay with gender deserves more attention. | lld:pubmed |
| pubmed-article:15567083 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15567083 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15567083 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15567083 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15567083 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15567083 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15567083 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15567083 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15567083 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15567083 | pubmed:issn | 0920-9964 | lld:pubmed |
| pubmed-article:15567083 | pubmed:author | pubmed-author:KeshavanMatch... | lld:pubmed |
| pubmed-article:15567083 | pubmed:author | pubmed-author:DuggalHarpree... | lld:pubmed |
| pubmed-article:15567083 | pubmed:author | pubmed-author:MuddasaniSrir... | lld:pubmed |
| pubmed-article:15567083 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15567083 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15567083 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:15567083 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15567083 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15567083 | pubmed:pagination | 113-20 | lld:pubmed |
| pubmed-article:15567083 | pubmed:dateRevised | 2010-9-2 | lld:pubmed |
| pubmed-article:15567083 | pubmed:meshHeading | pubmed-meshheading:15567083... | lld:pubmed |
| pubmed-article:15567083 | pubmed:meshHeading | pubmed-meshheading:15567083... | lld:pubmed |
| pubmed-article:15567083 | pubmed:meshHeading | pubmed-meshheading:15567083... | lld:pubmed |
| pubmed-article:15567083 | pubmed:meshHeading | pubmed-meshheading:15567083... | lld:pubmed |
| pubmed-article:15567083 | pubmed:meshHeading | pubmed-meshheading:15567083... | lld:pubmed |
| pubmed-article:15567083 | pubmed:meshHeading | pubmed-meshheading:15567083... | lld:pubmed |
| pubmed-article:15567083 | pubmed:meshHeading | pubmed-meshheading:15567083... | lld:pubmed |
| pubmed-article:15567083 | pubmed:meshHeading | pubmed-meshheading:15567083... | lld:pubmed |
| pubmed-article:15567083 | pubmed:meshHeading | pubmed-meshheading:15567083... | lld:pubmed |
| pubmed-article:15567083 | pubmed:meshHeading | pubmed-meshheading:15567083... | lld:pubmed |
| pubmed-article:15567083 | pubmed:meshHeading | pubmed-meshheading:15567083... | lld:pubmed |
| pubmed-article:15567083 | pubmed:meshHeading | pubmed-meshheading:15567083... | lld:pubmed |
| pubmed-article:15567083 | pubmed:meshHeading | pubmed-meshheading:15567083... | lld:pubmed |
| pubmed-article:15567083 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15567083 | pubmed:articleTitle | Insular volumes in first-episode schizophrenia: gender effect. | lld:pubmed |
| pubmed-article:15567083 | pubmed:affiliation | Room 441, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. | lld:pubmed |
| pubmed-article:15567083 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15567083 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15567083 | lld:pubmed |
