| pubmed-article:15565110 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15565110 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:15565110 | lifeskim:mentions | umls-concept:C0011581 | lld:lifeskim |
| pubmed-article:15565110 | lifeskim:mentions | umls-concept:C0003289 | lld:lifeskim |
| pubmed-article:15565110 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:15565110 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:15565110 | lifeskim:mentions | umls-concept:C0034897 | lld:lifeskim |
| pubmed-article:15565110 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:15565110 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:15565110 | lifeskim:mentions | umls-concept:C1414627 | lld:lifeskim |
| pubmed-article:15565110 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:15565110 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:15565110 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:15565110 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:15565110 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15565110 | pubmed:dateCreated | 2004-11-26 | lld:pubmed |
| pubmed-article:15565110 | pubmed:abstractText | The stress hormone-regulating hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the causality as well as the treatment of depression. To investigate a possible association between genes regulating the HPA axis and response to antidepressants and susceptibility for depression, we genotyped single-nucleotide polymorphisms in eight of these genes in depressed individuals and matched controls. We found significant associations of response to antidepressants and the recurrence of depressive episodes with single-nucleotide polymorphisms in FKBP5, a glucocorticoid receptor-regulating cochaperone of hsp-90, in two independent samples. These single-nucleotide polymorphisms were also associated with increased intracellular FKBP5 protein expression, which triggers adaptive changes in glucocorticoid receptor and, thereby, HPA-axis regulation. Individuals carrying the associated genotypes had less HPA-axis hyperactivity during the depressive episode. We propose that the FKBP5 variant-dependent alterations in HPA-axis regulation could be related to the faster response to antidepressant drug treatment and the increased recurrence of depressive episodes observed in this subgroup of depressed individuals. These findings support a central role of genes regulating the HPA axis in the causality of depression and the mechanism of action of antidepressant drugs. | lld:pubmed |
| pubmed-article:15565110 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15565110 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15565110 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15565110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15565110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15565110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15565110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15565110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15565110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15565110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15565110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15565110 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15565110 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15565110 | pubmed:issn | 1061-4036 | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:HolsboerFlori... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:RupprechtRain... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:BrunnerJürgen... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:BaghaiThomasT | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:UhrManfredM | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:ZillPeterP | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:BondyBrigitta... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:LiebRoselindR | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:PfisterHildeg... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:SeamanShaunS | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:BetteckenThom... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:MeitingerThom... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:BinderElisabe... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:ReinTheoT | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:LõhmussaarEli... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:KernNikolaN | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:Muller-Myhsok... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:IsingMarcusM | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:ModellSieglin... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:StromTim MTM | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:LichtnerPeter... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:DeimlTobiasT | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:NickelThomasT | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:PützBennoB | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:KünzelHeike... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:PapiolSergiS | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:PfennigAndrea... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:MuellerJakob... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:SalyakinaDari... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:WochnikGabrie... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:LucaeSusanneS | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:KohliMartin... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:FuchsBrigitte... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:MajerMatthias... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:MesserThomasT | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:KöhnleinOlive... | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:DabitzHeikeH | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:BrücklTanjaT | lld:pubmed |
| pubmed-article:15565110 | pubmed:author | pubmed-author:MüllerNinaN | lld:pubmed |
| pubmed-article:15565110 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15565110 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:15565110 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15565110 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15565110 | pubmed:pagination | 1319-25 | lld:pubmed |
| pubmed-article:15565110 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15565110 | pubmed:meshHeading | pubmed-meshheading:15565110... | lld:pubmed |
| pubmed-article:15565110 | pubmed:meshHeading | pubmed-meshheading:15565110... | lld:pubmed |
| pubmed-article:15565110 | pubmed:meshHeading | pubmed-meshheading:15565110... | lld:pubmed |
| pubmed-article:15565110 | pubmed:meshHeading | pubmed-meshheading:15565110... | lld:pubmed |
| pubmed-article:15565110 | pubmed:meshHeading | pubmed-meshheading:15565110... | lld:pubmed |
| pubmed-article:15565110 | pubmed:meshHeading | pubmed-meshheading:15565110... | lld:pubmed |
| pubmed-article:15565110 | pubmed:meshHeading | pubmed-meshheading:15565110... | lld:pubmed |
| pubmed-article:15565110 | pubmed:meshHeading | pubmed-meshheading:15565110... | lld:pubmed |
| pubmed-article:15565110 | pubmed:meshHeading | pubmed-meshheading:15565110... | lld:pubmed |
| pubmed-article:15565110 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15565110 | pubmed:articleTitle | Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. | lld:pubmed |
