| pubmed-article:15564339 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15564339 | lifeskim:mentions | umls-concept:C0034840 | lld:lifeskim |
| pubmed-article:15564339 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:15564339 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:15564339 | lifeskim:mentions | umls-concept:C1514762 | lld:lifeskim |
| pubmed-article:15564339 | lifeskim:mentions | umls-concept:C0034795 | lld:lifeskim |
| pubmed-article:15564339 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15564339 | pubmed:dateCreated | 2005-2-16 | lld:pubmed |
| pubmed-article:15564339 | pubmed:abstractText | The mechanisms of receptor- and cell-specific effects of the adrenal corticosteroid hormones via mineralo- (MRs) and glucocorticoid receptors (GRs) are still poorly understood. Because the expression levels of two splice variants of the steroid receptor coactivator-1 (SRC-1) 1a and 1e, can differ significantly in certain cell populations, we tested the hypothesis that their relative abundance could determine cell- and receptor-specific effects of corticosteroid receptor-mediated transcription. In transient transfections, we demonstrate three novel types of SRC-1a- and SRC-1e-specific effects for corticosteroid receptors. One is promoter dependence: SRC-1e much more potently coactivated transcription from several multiple response element-containing promoters. Mammalian 1-hydrid studies indicated that this likely does not involve promoter-specific coactivator recruitment. Endogenous phenylethanolamine-N-methyltransferase mRNA induction via GRs was also differentially affected by the splice variants. Another type is receptor specificity: responses mediated by the N-terminal part of the MR, but not the GR, were augmented by SRC-1e at synergizing response elements. SRC fragment SRC(988-1240) by the MR but not the GR N-terminal fragment in a 1-hybrid assay. The last type, for GRs, is ligand dependence. Due to effects on partial agonism of RU486-activated GRs, different ratios of SRC-1a and 1e can lead to large differences in the extent of antagonism of RU486 on GR-mediated transcription. Furthermore, we show that SRC-1e but not SRC-1a mRNA expression was regulated in the pituitary by corticosterone. We conclude that the cellular differences in SRC-1a to SRC-1e ratio demonstrated in vivo might be involved in cell-specific responses to corticosteroids in a promoter- and ligand-dependent way. | lld:pubmed |
| pubmed-article:15564339 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15564339 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15564339 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15564339 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15564339 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15564339 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15564339 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15564339 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15564339 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15564339 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15564339 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15564339 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15564339 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15564339 | pubmed:issn | 0013-7227 | lld:pubmed |
| pubmed-article:15564339 | pubmed:author | pubmed-author:de KloetE RER | lld:pubmed |
| pubmed-article:15564339 | pubmed:author | pubmed-author:PearceDD | lld:pubmed |
| pubmed-article:15564339 | pubmed:author | pubmed-author:MeijerO COC | lld:pubmed |
| pubmed-article:15564339 | pubmed:author | pubmed-author:KalkhovenEE | lld:pubmed |
| pubmed-article:15564339 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:15564339 | pubmed:author | pubmed-author:SteenbergenP... | lld:pubmed |
| pubmed-article:15564339 | pubmed:author | pubmed-author:HoutmanS HSH | lld:pubmed |
| pubmed-article:15564339 | pubmed:author | pubmed-author:DijkmansT FTF | lld:pubmed |
| pubmed-article:15564339 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15564339 | pubmed:volume | 146 | lld:pubmed |
| pubmed-article:15564339 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15564339 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15564339 | pubmed:pagination | 1438-48 | lld:pubmed |
| pubmed-article:15564339 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:meshHeading | pubmed-meshheading:15564339... | lld:pubmed |
| pubmed-article:15564339 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15564339 | pubmed:articleTitle | Steroid receptor coactivator-1 splice variants differentially affect corticosteroid receptor signaling. | lld:pubmed |
| pubmed-article:15564339 | pubmed:affiliation | Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research and Leiden University Medical Center, Leiden University, P.O. Box 9503, 2300 RA Leiden, The Netherlands. o.meijer@lacdr.leidenuniv.nl | lld:pubmed |
| pubmed-article:15564339 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15564339 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:24661 | entrezgene:pubmed | pubmed-article:15564339 | lld:entrezgene |
| entrez-gene:313929 | entrezgene:pubmed | pubmed-article:15564339 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15564339 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15564339 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15564339 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15564339 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15564339 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15564339 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15564339 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15564339 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15564339 | lld:pubmed |
