| pubmed-article:15563472 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15563472 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15563472 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:15563472 | lifeskim:mentions | umls-concept:C0812201 | lld:lifeskim |
| pubmed-article:15563472 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:15563472 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15563472 | lifeskim:mentions | umls-concept:C1334509 | lld:lifeskim |
| pubmed-article:15563472 | lifeskim:mentions | umls-concept:C1366765 | lld:lifeskim |
| pubmed-article:15563472 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15563472 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15563472 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15563472 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15563472 | pubmed:dateCreated | 2005-2-7 | lld:pubmed |
| pubmed-article:15563472 | pubmed:abstractText | Interleukins (IL)-2 and IL-15 regulate natural killer (NK) cell proliferation, survival, and cytolytic activity. Ets1 is a transcription factor expressed early in NK cell differentiation. Because IL-2Rbeta, IL-2Rgamma, IL-15, and Ets1 knock-out mice similarly lack NK cells, we explored a molecular connection between IL-2R signaling and Ets1. Here we report the post-transcriptional regulation of Ets1 by IL-2R signaling in human NK cells. IL-2 and IL-15 stimulation leads to increased Ets1 protein levels with no significant change in mRNA levels. Pulse and pulse-chase experiments show that IL-2 stimulation results in both a marked increase in the nascent translation of Ets1 and an increased protein half-life. Pharmacological inhibition of MEK specifically blocks IL-2- and IL-15-induced translation, whereas p38, phosphatidylinositol 3-kinase, and mTOR inhibitors had no effect on Ets1 levels. Fli1, an Ets family member, exhibited a different mechanism of regulation, illustrating the specificity of IL-2R beta and gamma subunit signaling on the regulation of Ets1 expression. Expression of a dominant negative form of MNK1, a regulator of the translation initiation factor eIF4E, blocks the expression of Ets1 as do the dominant negative forms of the common IL-2R beta and gamma chains. Expression of Ets1 is regulated similarly in normal peripheral human NK cells. Taken together, our findings provide a direct link between IL-2R subunit signaling and Ets1 expression and helps to explain the interdependence of the IL-2R subunits and Ets1 for NK cell development and function. | lld:pubmed |
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| pubmed-article:15563472 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15563472 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15563472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15563472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15563472 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15563472 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15563472 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15563472 | pubmed:author | pubmed-author:WatsonDennis... | lld:pubmed |
| pubmed-article:15563472 | pubmed:author | pubmed-author:SpyropoulosDe... | lld:pubmed |
| pubmed-article:15563472 | pubmed:author | pubmed-author:Muise-Helmeri... | lld:pubmed |
| pubmed-article:15563472 | pubmed:author | pubmed-author:GrundEric MEM | lld:pubmed |
| pubmed-article:15563472 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15563472 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:15563472 | pubmed:volume | 280 | lld:pubmed |
| pubmed-article:15563472 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15563472 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15563472 | pubmed:pagination | 4772-8 | lld:pubmed |
| pubmed-article:15563472 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:15563472 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15563472 | pubmed:articleTitle | Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells. | lld:pubmed |
| pubmed-article:15563472 | pubmed:affiliation | Department of Cell Biology and Anatomy, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA. | lld:pubmed |
| pubmed-article:15563472 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15563472 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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