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pubmed-article:15563360pubmed:abstractTextIbandronate, a highly potent nitrogen-containing bisphosphonate, is the subject of an ongoing clinical development programme that aims to maximize the potential of simplified, less frequent oral and intravenous (i.v.) administration in osteoporosis. A modelling and simulation project was undertaken to characterize further the clinical pharmacology of ibandronate and identify convenient intermittent oral and i.v. regimens for clinical evaluation.lld:pubmed
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pubmed-article:15563360pubmed:articleTitleA semimechanistic and mechanistic population PK-PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis.lld:pubmed
pubmed-article:15563360pubmed:affiliationModelling and Simulation Team, F. Hoffmann-La Roche, Basel, Switzerland. goonaseelan.pillai@pharma.novartis.comlld:pubmed
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