| pubmed-article:15557821 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15557821 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15557821 | lifeskim:mentions | umls-concept:C0237401 | lld:lifeskim |
| pubmed-article:15557821 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15557821 | lifeskim:mentions | umls-concept:C0031670 | lld:lifeskim |
| pubmed-article:15557821 | lifeskim:mentions | umls-concept:C0256371 | lld:lifeskim |
| pubmed-article:15557821 | lifeskim:mentions | umls-concept:C0700624 | lld:lifeskim |
| pubmed-article:15557821 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:15557821 | lifeskim:mentions | umls-concept:C0323677 | lld:lifeskim |
| pubmed-article:15557821 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:15557821 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:15557821 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:15557821 | lifeskim:mentions | umls-concept:C0525838 | lld:lifeskim |
| pubmed-article:15557821 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15557821 | pubmed:dateCreated | 2004-11-23 | lld:pubmed |
| pubmed-article:15557821 | pubmed:abstractText | The major house-dust mite allergen, Der f 2, stimulates the phospholipase D (PLD) in T lymphocytes from Dermatophagoides farinae specific allergic individuals. PLD activity increased more than two-fold in T cells from allergic patients compared with those cells from normal controls with maximal responses within 30 min after exposure of Der f 2. A well-known PLD activator PKC-alpha was found to be translocated to membrane from cytosol in Der f 2-treated T cells from Dermatophagoides farinae specific allergic individuals. Down-regulation of PKC-alpha with phorbol myristate acetate pretreatment for 24 h abolished Der f 2-induced PLD activation. Ro 320432, PKC inhibitor also reduced the effects of Der f 2-induced PLD activation suggesting that PKC-alpha acts as upstream activator of PLD in Der f 2-treated T cells. Taken together, the present data suggest that Der f 2 can stimulate PLD activity through the PKC-alpha activation in T cells from Dermatophagoides farinae allergic individuals. | lld:pubmed |
| pubmed-article:15557821 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15557821 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15557821 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15557821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15557821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15557821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15557821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15557821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15557821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15557821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15557821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15557821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15557821 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15557821 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15557821 | pubmed:issn | 1226-3613 | lld:pubmed |
| pubmed-article:15557821 | pubmed:author | pubmed-author:OhJae-WonJW | lld:pubmed |
| pubmed-article:15557821 | pubmed:author | pubmed-author:KimEun-YoungE... | lld:pubmed |
| pubmed-article:15557821 | pubmed:author | pubmed-author:HanJoong-SooJ... | lld:pubmed |
| pubmed-article:15557821 | pubmed:author | pubmed-author:KimYong-SeokY... | lld:pubmed |
| pubmed-article:15557821 | pubmed:author | pubmed-author:LeeKi SungKS | lld:pubmed |
| pubmed-article:15557821 | pubmed:author | pubmed-author:KooBon-SukBS | lld:pubmed |
| pubmed-article:15557821 | pubmed:author | pubmed-author:LeeHa BaikHB | lld:pubmed |
| pubmed-article:15557821 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15557821 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:15557821 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:15557821 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15557821 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15557821 | pubmed:pagination | 486-92 | lld:pubmed |
| pubmed-article:15557821 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:15557821 | pubmed:meshHeading | pubmed-meshheading:15557821... | lld:pubmed |
| pubmed-article:15557821 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15557821 | pubmed:articleTitle | Der f 2 activates phospholipase D in human T lymphocytes from Dermatophagoides farinae specific allergic individuals: involvement of protein kinase C-alpha. | lld:pubmed |
| pubmed-article:15557821 | pubmed:affiliation | Department of Pediatrics, Department of Biochemistry, College of Medicine, Hanyang University, Seoul 133-791, Korea. jshan@hanyang.ac.kr | lld:pubmed |
| pubmed-article:15557821 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15557821 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15557821 | lld:pubmed |
