| pubmed-article:15556941 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15556941 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15556941 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15556941 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:15556941 | lifeskim:mentions | umls-concept:C0245662 | lld:lifeskim |
| pubmed-article:15556941 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:15556941 | lifeskim:mentions | umls-concept:C0252527 | lld:lifeskim |
| pubmed-article:15556941 | lifeskim:mentions | umls-concept:C0035253 | lld:lifeskim |
| pubmed-article:15556941 | lifeskim:mentions | umls-concept:C1539477 | lld:lifeskim |
| pubmed-article:15556941 | lifeskim:mentions | umls-concept:C1749570 | lld:lifeskim |
| pubmed-article:15556941 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:15556941 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:15556941 | pubmed:dateCreated | 2005-2-21 | lld:pubmed |
| pubmed-article:15556941 | pubmed:abstractText | Galectins have emerged as a novel family of immunoregulatory proteins implicated in T cell homeostasis. Recent studies showed that galectin-1 (Gal-1) plays a key role in tumor-immune escape by killing antitumor effector T cells. Here we found that Gal-1 sensitizes human resting T cells to Fas (CD95)/caspase-8-mediated cell death. Furthermore, this protein triggers an apoptotic program involving an increase of mitochondrial membrane potential and participation of the ceramide pathway. In addition, Gal-1 induces mitochondrial coalescence, budding, and fission accompanied by an increase and/or redistribution of fission-associated molecules h-Fis and DRP-1. Importantly, these changes are detected in both resting and activated human T cells, suggesting that Gal-1-induced cell death might become an excellent model to analyze the morphogenetic changes of mitochondria during the execution of cell death. This is the first association among Gal-1, Fas/Fas ligand-mediated cell death, and the mitochondrial pathway, providing a rational basis for the immunoregulatory properties of Gal-1 in experimental models of chronic inflammation and cancer. | lld:pubmed |
| pubmed-article:15556941 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15556941 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15556941 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15556941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15556941 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15556941 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15556941 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15556941 | pubmed:author | pubmed-author:RabinovichGab... | lld:pubmed |
| pubmed-article:15556941 | pubmed:author | pubmed-author:MalorniWalter... | lld:pubmed |
| pubmed-article:15556941 | pubmed:author | pubmed-author:MatarresePaol... | lld:pubmed |
| pubmed-article:15556941 | pubmed:author | pubmed-author:AscioneBarbar... | lld:pubmed |
| pubmed-article:15556941 | pubmed:author | pubmed-author:TinariAntonel... | lld:pubmed |
| pubmed-article:15556941 | pubmed:author | pubmed-author:ToscanoMarta... | lld:pubmed |
| pubmed-article:15556941 | pubmed:author | pubmed-author:MormoneElisab... | lld:pubmed |
| pubmed-article:15556941 | pubmed:author | pubmed-author:BiancoGermán... | lld:pubmed |
| pubmed-article:15556941 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15556941 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:15556941 | pubmed:volume | 280 | lld:pubmed |
| pubmed-article:15556941 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15556941 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15556941 | pubmed:pagination | 6969-85 | lld:pubmed |
| pubmed-article:15556941 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15556941 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15556941 | pubmed:articleTitle | Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission. | lld:pubmed |
| pubmed-article:15556941 | pubmed:affiliation | Department of Drug Research and Evaluation, and Technology and Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, Rome 00161, Italy. | lld:pubmed |
| pubmed-article:15556941 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15556941 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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