| pubmed-article:15549330 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15549330 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:15549330 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:15549330 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:15549330 | lifeskim:mentions | umls-concept:C0010656 | lld:lifeskim |
| pubmed-article:15549330 | lifeskim:mentions | umls-concept:C0270733 | lld:lifeskim |
| pubmed-article:15549330 | lifeskim:mentions | umls-concept:C0393571 | lld:lifeskim |
| pubmed-article:15549330 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:15549330 | lifeskim:mentions | umls-concept:C0231174 | lld:lifeskim |
| pubmed-article:15549330 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:15549330 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15549330 | pubmed:dateCreated | 2005-3-25 | lld:pubmed |
| pubmed-article:15549330 | pubmed:abstractText | In the present study we assessed the neuroprotective effects of the pan-caspase inhibitor z-VAD.fmk [N-benzyloxycarbony-valine-alanine-aspartate-(OMe)-fluoromethylketone], and the caspase-3 inhibitor Ac-DEVD.CHO (acetyl-aspartate-chloromethylketone) in the double-lesion rat model of striatonigral degeneration (SND), the core pathology underlying levodopa-unresponsive parkinsonism associated with multiple system atrophy (MSA). Male Wistar rats were divided into three groups, receiving either Ac-DEVD.CHO, z-VAD.fmk or normal saline before lesion surgery, comprising a sequential unilateral quinolinic acid (QA) lesion of the striatum followed by a 6-hydroxydopamine (6-OHDA) lesion of the ipsilateral medial forebrain bundle. At 2 weeks post lesion, all rats underwent testing of spontaneous nocturnal locomotor behavior in an automated Photobeam Activity System (FlexField). Immunohistochemistry was performed with tyrosine hydroxylase, dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein and glial fibrillary acidic protein antibodies. Morphometry was performed using computerized image analysis. Behavioral and morphological analysis failed to show striatal or nigral protection in caspase inhibitor-treated animals. Our findings suggest that anti-apoptotic strategies are unrewarding in the SND rat model and, therefore, alternative neuroprotective interventions such as anti-glutamatergic agents or inhibitors of microglial activation should be explored instead. | lld:pubmed |
| pubmed-article:15549330 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15549330 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15549330 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15549330 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15549330 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15549330 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15549330 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15549330 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15549330 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15549330 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15549330 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15549330 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15549330 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15549330 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15549330 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15549330 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15549330 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15549330 | pubmed:issn | 0001-6322 | lld:pubmed |
| pubmed-article:15549330 | pubmed:author | pubmed-author:JellingerKurt... | lld:pubmed |
| pubmed-article:15549330 | pubmed:author | pubmed-author:PoeweWernerW | lld:pubmed |
| pubmed-article:15549330 | pubmed:author | pubmed-author:WenningGregor... | lld:pubmed |
| pubmed-article:15549330 | pubmed:author | pubmed-author:StefanovaNadi... | lld:pubmed |
| pubmed-article:15549330 | pubmed:author | pubmed-author:EggerKarl EKE | lld:pubmed |
| pubmed-article:15549330 | pubmed:author | pubmed-author:MantoanLauraL | lld:pubmed |
| pubmed-article:15549330 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15549330 | pubmed:volume | 109 | lld:pubmed |
| pubmed-article:15549330 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15549330 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15549330 | pubmed:pagination | 191-7 | lld:pubmed |
| pubmed-article:15549330 | pubmed:dateRevised | 2007-11-9 | lld:pubmed |
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| pubmed-article:15549330 | pubmed:meshHeading | pubmed-meshheading:15549330... | lld:pubmed |
| pubmed-article:15549330 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15549330 | pubmed:articleTitle | Failure of caspase inhibition in the double-lesion rat model of striatonigral degeneration (multiple system atrophy). | lld:pubmed |
| pubmed-article:15549330 | pubmed:affiliation | Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria. | lld:pubmed |
| pubmed-article:15549330 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15549330 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15549330 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
