Linked Life Data

15548215

Source:http://linkedlifedata.com/resource/pubmed/id/15548215

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pubmed-article:15548215pubmed:dateCreated2004-11-19lld:pubmed
pubmed-article:15548215pubmed:abstractTextThe purpose of this study was to identify the networks involved in the regulation of visual accommodation/vergence by contrasting the cortical functions subservient to eye-lens accommodation with those evoked by foveal fixation. Neural activity was assessed in normal volunteers by changes in rCBF measured with PET. Thirteen right-handed subjects participated in three monocular tasks: (i) resting with eyes closed; (ii) sustained foveal fixation upon a LED at 1.2 m (0.83 D); and (iii) accommodating alternately on a near (24 cm, 4.16 D) vs. a far (3.0 m, 0.33 D) LED alternately illuminated in sequential 2 s epochs. The contrast between the conditions of near/far accommodation and of constant foveal fixation revealed activation in cerebellar hemispheres and vermis; middle and inferior temporal cortex (BA 20, 21, 37); striate cortex and associative visual areas (BA 17/18). Comparison of the condition of constant fixation with the condition of resting with closed eyes indicated activation of cerebellar hemispheres and vermis; visual cortices (BA 17/18); a right hemisphere dominant network encompassing prefrontal (BA 6, 9, 47), superior parietal (BA 7), and superior temporal (BA 40) cortices; and bilateral thalamus. The contrast between the conditions of near/far accommodation with closed-eye rest reflected an incremental summation of the activations found in the previous comparisons (i.e. activations associated with constant fixation). Neural circuits activated selectively during the near/far response to blur cues over those during constant visual fixation, occupy posterior structures that include occipital visual regions, cerebellar hemispheres and vermis, and temporal cortex.lld:pubmed
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pubmed-article:15548215pubmed:authorpubmed-author:PardoJosé VJVlld:pubmed
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pubmed-article:15548215pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:15548215pubmed:articleTitleFunctional neuroanatomy of the human near/far response to blur cues: eye-lens accommodation/vergence to point targets varying in depth.lld:pubmed
pubmed-article:15548215pubmed:affiliationDepartment of Ophthalmology, Karolinska Institute, Huddinge, Sweden. hrr@hig.selld:pubmed
pubmed-article:15548215pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15548215pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:15548215pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
pubmed-article:15548215pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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