| pubmed-article:15545994 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15545994 | lifeskim:mentions | umls-concept:C0256073 | lld:lifeskim |
| pubmed-article:15545994 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:15545994 | lifeskim:mentions | umls-concept:C1518440 | lld:lifeskim |
| pubmed-article:15545994 | lifeskim:mentions | umls-concept:C0234402 | lld:lifeskim |
| pubmed-article:15545994 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:15545994 | lifeskim:mentions | umls-concept:C0443254 | lld:lifeskim |
| pubmed-article:15545994 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15545994 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:15545994 | pubmed:dateCreated | 2004-11-16 | lld:pubmed |
| pubmed-article:15545994 | pubmed:abstractText | Polycystin-1, which is encoded by a gene that is mutated in autosomal dominant polycystic kidney disease (ADPKD), is involved in cell-matrix interactions as well as in ciliary signaling. The precise mechanisms by which it functions, however, remain unclear. Here we find that polycystin-1 undergoes a proteolytic cleavage that releases its C-terminal tail (CTT), which enters the nucleus and initiates signaling processes. The cleavage occurs in vivo in association with alterations in mechanical stimuli. Polycystin-2, the product of the second gene mutated in ADPKD, modulates the signaling properties of the polycystin-1 CTT. These data reveal a novel pathway by which polycystin-1 transmits messages directly to the nucleus. | lld:pubmed |
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| pubmed-article:15545994 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15545994 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15545994 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15545994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15545994 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15545994 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15545994 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15545994 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:15545994 | pubmed:author | pubmed-author:CaplanMichael... | lld:pubmed |
| pubmed-article:15545994 | pubmed:author | pubmed-author:HiesbergerTho... | lld:pubmed |
| pubmed-article:15545994 | pubmed:author | pubmed-author:SomloStefanS | lld:pubmed |
| pubmed-article:15545994 | pubmed:author | pubmed-author:Ibraghimov-Be... | lld:pubmed |
| pubmed-article:15545994 | pubmed:author | pubmed-author:IgarashiPeter... | lld:pubmed |
| pubmed-article:15545994 | pubmed:author | pubmed-author:BennettAnton... | lld:pubmed |
| pubmed-article:15545994 | pubmed:author | pubmed-author:WangTongT | lld:pubmed |
| pubmed-article:15545994 | pubmed:author | pubmed-author:TianXinX | lld:pubmed |
| pubmed-article:15545994 | pubmed:author | pubmed-author:ChauvetVeroni... | lld:pubmed |
| pubmed-article:15545994 | pubmed:author | pubmed-author:GrimmDavid... | lld:pubmed |
| pubmed-article:15545994 | pubmed:author | pubmed-author:HussonHerveH | lld:pubmed |
| pubmed-article:15545994 | pubmed:author | pubmed-author:HiesebergerTh... | lld:pubmed |
| pubmed-article:15545994 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15545994 | pubmed:volume | 114 | lld:pubmed |
| pubmed-article:15545994 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15545994 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15545994 | pubmed:pagination | 1433-43 | lld:pubmed |
| pubmed-article:15545994 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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