| pubmed-article:15545345 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15545345 | lifeskim:mentions | umls-concept:C1655052 | lld:lifeskim |
| pubmed-article:15545345 | pubmed:issue | 1-4 | lld:pubmed |
| pubmed-article:15545345 | pubmed:dateCreated | 2004-11-16 | lld:pubmed |
| pubmed-article:15545345 | pubmed:abstractText | The approach that most animal cells employ to regulate intracellular pH (pH(i)) is not too different conceptually from the way a sophisticated system might regulate the temperature of a house. Just as the heat capacity (C) of a house minimizes sudden temperature (T) shifts caused by acute cold and heat loads, the buffering power (beta) of a cell minimizes sudden pH(i) shifts caused by acute acid and alkali loads. However, increasing C (or beta) only minimizes T (or pH(i)) changes; it does not eliminate the changes, return T (or pH(i)) to normal, or shift steady-state T (or pH(i)). Whereas a house may have a furnace to raise T, a cell generally has more than one acid-extruding transporter (which exports acid and/or imports alkali) to raise pH(i). Whereas an air conditioner lowers T, a cell generally has more than one acid-loading transporter to lower pH(i). Just as a house might respond to graded decreases (or increases) in T by producing graded increases in heat (or cold) output, cells respond to graded decreases (or increases) in pH(i) with graded increases (or decreases) in acid-extrusion (or acid-loading) rate. Steady-state T (or pH(i)) can change only in response to a change in chronic cold (or acid) loading or chronic heat (or alkali) loading as produced, for example, by a change in environmental T (or pH) or a change in the kinetics of the furnace (or acid extrudes) or air conditioner (or acid loaders). Finally, just as a temperature-control system might benefit from environmental sensors that provide clues about cold and heat loading, at least some cells seem to have extracellular CO(2) or extracellular HCO(3)(-) sensors that modulate acid-base transport. | lld:pubmed |
| pubmed-article:15545345 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15545345 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15545345 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15545345 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15545345 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15545345 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15545345 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15545345 | pubmed:issn | 1043-4046 | lld:pubmed |
| pubmed-article:15545345 | pubmed:author | pubmed-author:BoronWalter... | lld:pubmed |
| pubmed-article:15545345 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15545345 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:15545345 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15545345 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15545345 | pubmed:pagination | 160-79 | lld:pubmed |
| pubmed-article:15545345 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:15545345 | pubmed:meshHeading | pubmed-meshheading:15545345... | lld:pubmed |
| pubmed-article:15545345 | pubmed:meshHeading | pubmed-meshheading:15545345... | lld:pubmed |
| pubmed-article:15545345 | pubmed:meshHeading | pubmed-meshheading:15545345... | lld:pubmed |
| pubmed-article:15545345 | pubmed:meshHeading | pubmed-meshheading:15545345... | lld:pubmed |
| pubmed-article:15545345 | pubmed:meshHeading | pubmed-meshheading:15545345... | lld:pubmed |
| pubmed-article:15545345 | pubmed:meshHeading | pubmed-meshheading:15545345... | lld:pubmed |
| pubmed-article:15545345 | pubmed:meshHeading | pubmed-meshheading:15545345... | lld:pubmed |
| pubmed-article:15545345 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15545345 | pubmed:articleTitle | Regulation of intracellular pH. | lld:pubmed |
| pubmed-article:15545345 | pubmed:affiliation | Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8026, USA. walter.boron@yale.edu | lld:pubmed |
| pubmed-article:15545345 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15545345 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15545345 | pubmed:publicationType | Review | lld:pubmed |
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