| pubmed-article:15542045 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15542045 | lifeskim:mentions | umls-concept:C0262950 | lld:lifeskim |
| pubmed-article:15542045 | lifeskim:mentions | umls-concept:C0031603 | lld:lifeskim |
| pubmed-article:15542045 | lifeskim:mentions | umls-concept:C1414605 | lld:lifeskim |
| pubmed-article:15542045 | lifeskim:mentions | umls-concept:C0449416 | lld:lifeskim |
| pubmed-article:15542045 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15542045 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15542045 | pubmed:dateCreated | 2004-11-15 | lld:pubmed |
| pubmed-article:15542045 | pubmed:abstractText | The identification of FGF23 as a factor involved in several disorders of phosphate regulation and of PHEX as the gene mutated in X-linked Hypophosphatemic Rickets indicates that both these genes may be involved in phosphate homeostasis, although their physiological roles are unclear. In this study, FGF23 mRNA expression was analyzed by real-time RT-PCR and found to be higher in normal human bone than in kidney, liver, thyroid, or parathyroid tissue, while expression in oncogenic osteomalacia tumor tissue was several hundred-fold higher than in bone. Expression of FGF23 mRNA in human osteoblast-like bone cells, quantitated by real-time RT-PCR, increased with increasing extracellular phosphate and was 2-fold higher in cells treated with 2 mM extracellular phosphate compared to 0 mM phosphate treatment. PHEX mRNA expression increased 1.3-fold after treatment with 2 mM phosphate. FGF23 expression in the bone cells increased with increased mineralization over a 20-day treatment period under mineralizing conditions with beta-glycerophosphate, while PHEX expression decreased. The results indicate that FGF23 mRNA expression in bone cells is regulated by extracellular phosphate and by mineralization. These results support proposals that bone may be a source of circulating FGF23 and suggest that FGF23 expression by bone is regulated. | lld:pubmed |
| pubmed-article:15542045 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15542045 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15542045 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15542045 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15542045 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15542045 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15542045 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15542045 | pubmed:issn | 8756-3282 | lld:pubmed |
| pubmed-article:15542045 | pubmed:author | pubmed-author:NelsonAnne... | lld:pubmed |
| pubmed-article:15542045 | pubmed:author | pubmed-author:MasonRebecca... | lld:pubmed |
| pubmed-article:15542045 | pubmed:author | pubmed-author:RobinsonBruce... | lld:pubmed |
| pubmed-article:15542045 | pubmed:author | pubmed-author:MiramsMichiko... | lld:pubmed |
| pubmed-article:15542045 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15542045 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:15542045 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15542045 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15542045 | pubmed:pagination | 1192-9 | lld:pubmed |
| pubmed-article:15542045 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15542045 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15542045 | pubmed:articleTitle | Bone as a source of FGF23: regulation by phosphate? | lld:pubmed |
| pubmed-article:15542045 | pubmed:affiliation | Department of Physiology, Institute for Biomedical Research F13, University of Sydney, Sydney NSW 2006, Australia. mmirams@med.usyd.edu.au | lld:pubmed |
| pubmed-article:15542045 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15542045 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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